Differences of apathy perfusion correlates between Alzheimer's disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis.

International Journal of Psychiatry in Clinical Practice
Varvara ValotassiouJohn Papatriantafyllou

Abstract

To explore differences of apathy perfusion correlates between Alzheimer's disease (AD) and Frontotemporal dementia (FTD) using perfusion SPECT. We studied 75 FTD and 66 AD patients. We evaluated apathy using Neuropsychiatric Inventory (NPI). We compared perfusion of BAs on left (L) and right (R) hemisphere in AD and FTD. Apathy in AD was significantly and negatively correlated with dorsolateral prefrontal cortex bilaterally, right anterior prefrontal cortex, inferior frontal cortex bilaterally, especially on the right, orbital part of inferior frontal gyrus bilaterally, left dorsal anterior cingulate cortex, right primary and secondary visual cortex, and with bilateral anterior and dorsolateral prefrontal cortex, inferior frontal cortex and orbital part of inferior frontal gyrus, bilaterally, bilateral anterior -ventral and dorsal- cingulate cortex, left posterior ventral cingulate cortex, right inferior, middle and anterior temporal gyri, entorhinal and parahippocampal cortex in FTD. Significant overlapping of apathy perfusion correlates between AD and FTD is seen in frontal areas and anterior cingulate. Right occipital cortex is also involved in AD, while right temporal cortex and left posterior cingulate are involved in FTD....Continue Reading

References

Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·S E StarksteinR G Robinson
Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Jan 1, 1991·The Journal of Neuropsychiatry and Clinical Neurosciences·R S Marin
Feb 1, 1995·Brain : a Journal of Neurology·O DevinskyB A Vogt
Nov 1, 1996·Archives of Neurology·A H CraigI Mena
Aug 26, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·M L LevyI Litvan
Jan 22, 2000·Radiology·J W BurrussL A Hayman
Feb 24, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·O L LopezS T DeKosky
Apr 6, 2001·Seminars in Clinical Neuropsychiatry·T W McAllister
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·George BushBruce R Rosen
Apr 10, 2002·Journal of the International Neuropsychological Society : JINS·Susan McPhersonCarla Back-Madruga
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Constantine G LyketsosSteven DeKosky
Sep 8, 2004·International Journal of Geriatric Psychiatry·M BenoitP H Robert
Jan 26, 2005·Annals of Neurology·Massimo FranceschiDaniela Perani
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Robert van ReekumLaurie Ostrander
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR Mizrahi
Oct 7, 2005·Cerebral Cortex·Richard Levy, Bruno Dubois
Dec 13, 2005·Dementia and Geriatric Cognitive Disorders·Shunichiro ShinagawaHirotaka Tanabe
Mar 15, 2006·Dementia and Geriatric Cognitive Disorders·Frédéric PetersEric Salmon
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P H RobertJ Darcourt
Apr 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Donald T Stuss, Michael P Alexander
Apr 10, 2007·Annals of the New York Academy of Sciences·Masamichi Sakagami, Masataka Watanabe
Jun 15, 2007·Dementia and Geriatric Cognitive Disorders·Krista L LanctôtSandra E Black
Jun 16, 2007·Dementia and Geriatric Cognitive Disorders·Liana G ApostolovaPaul M Thompson
Jul 11, 2007·Archives of Neurology·Gad A MarshallDavid L Sultzer
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 2, 2008·Brain : a Journal of Neurology·Peita D BruenAnnalena Venneri
Nov 6, 2008·Social Cognitive and Affective Neuroscience·William D S Killgore, Deborah A Yurgelun-Todd
Feb 10, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·P RobertJ Byrne
Apr 20, 2010·Journal of the Neurological Sciences·Jonathan D Rohrer, Jason D Warren
May 18, 2010·Neurotoxicity Research·Thomas N Chase
Sep 28, 2010·International Journal of Geriatric Psychiatry·C TunnardUNKNOWN AddNeuroMed Consortium
Jun 29, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jee Wook KimJong Inn Woo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.