Differences of physical vs. psychological stress: evidences from glucocorticoid receptor expression, hippocampal subfields injury, and behavioral abnormalities

Brain Imaging and Behavior
Yuefeng LiShenghong Ju

Abstract

The glucocorticoid receptor (GR) is the main effector of the activation of the hypothalamus-pituitary-adrenal (HPA) axis, which is caused by different types of stress that can be divided into two major categories: physical stress and psychological stress. Given the marked presence of GR in the hippocampus, GR-mediated hippocampal injury might be the core event under stress. The aim of this study was to investigate GR expression, hippocampal injury, and behaviors in rats to explore the differences between these types of stressors. Adult male rats were stressed using a classical model (electrical foot shock and a yoked psychologically stressful situation) to induce physical or psychological stress. The GR expression, injury of hippocampal subfields and behavioral abnormalities were dynamic, as demonstrated using immunofluorescence, 3D magnetic resonance imaging (MRI) and open field exploration (OFE), respectively. In addition, housing in a normal environment for 6 weeks was used to verify the recovery ability of rats. First, GR-mediated hippocampal atrophy and behavioral abnormalities were found in the second week under physical stress, but those changes did not appear until the fourth week under psychological stress. Second, the...Continue Reading

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Nov 28, 2017·Brain Research Bulletin·Yuefeng LiShenghong Ju
Jun 29, 2018·Frontiers in Psychiatry·Simeng GuFushun Wang

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Citations

Feb 23, 2020·International Journal of Molecular Sciences·Zhuang MiaoZhongsheng Sun
Nov 17, 2020·Frontiers in Aging Neuroscience·Marina Ávila-VillanuevaMiguel A Fernández-Blázquez
Jul 7, 2021·Biochemistry. Biokhimii︠a︡·Leonid G Khaspekov

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