PMID: 11934651Apr 6, 2002Paper

Differences of three-dimensional trabecular microstructure in osteopenic rat models caused by ovariectomy and neurectomy

Bone
M ItoK Hayashi

Abstract

We investigated the differences in three-dimensional microstructure of bone in cases of osteopenia caused by two different procedures: ovariectomy (ovx) and sciatic neurectomy (nx). Thirty-nine 8-week-old female Lewis rats were divided into two groups: (1) ovx and sham operation; and (2) nx and sham operation. At 12 weeks of age these rats were killed to sample the right tibiae. The samples were scanned using microcomputed tomography to obtain metric parameters such as bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp), and nonmetric parameters such as structure model index (SMI), trabecular bone pattern factor (TBPf), and degree of anisotropy (DA). The changes in all microstructural parameters were significant in both the ovx and nx groups, with those of BV/TV, Tb.Th, Tb.Sp, and SMI more significant in the ovx group than in the nx group, in comparison to their respective controls. The significantly higher coefficient of variance for Tb.Th across the entire analyzed area of the individual samples indicated that the trabecular thinning occurred heterogenously and that the microstructural deterioration induced by ovx and nx appeared to be locally accelerated, so as to induce perforation ...Continue Reading

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Citations

Jun 30, 2005·Journal of Bone and Mineral Metabolism·Jürg A GasserBruno Koller
Jun 30, 2005·Journal of Bone and Mineral Metabolism·Masako Ito
Sep 1, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jill M SladeGary A Dudley
Feb 16, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Masako ItoMasahiro Kawase
Mar 8, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Marcus EgermannE Schneider
Jan 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-D JiangL-Y Dai
Dec 13, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M ModleskyG A Dudley
Sep 30, 2004·Calcified Tissue International·Gloria E Lopez FrancoRobert D Blank
Feb 9, 2011·Journal of Bone and Mineral Metabolism·Masako Ito
Jun 21, 2008·International Journal of Biological Sciences·Hansjoerg HeepMarius von Knoch
Apr 12, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S K AmugongoN E Lane
May 29, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Vivien KauschkeReinhard Schnettler
Aug 3, 2010·Micron : the International Research and Review Journal for Microscopy·L P NogueiraG Tromba
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Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Valentin DavidLaurence Vico
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher M ModleskyGary A Dudley
Jan 1, 2004·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·R E GuldbergW R Taylor
Jul 15, 2015·Calcified Tissue International·Jens Bay VeggerJesper Skovhus Thomsen
Feb 18, 2015·Stem Cell Research & Therapy·Joel D BoerckelEben Alsberg

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