Different aberrant mentalizing networks in males and females with autism spectrum disorders: Evidence from resting-state functional magnetic resonance imaging

Autism : the International Journal of Research and Practice
Jie Yang, Jonathan Lee

Abstract

Previous studies have found that individuals with autism spectrum disorders show impairments in mentalizing processes and aberrant brain activity compared with typically developing participants. However, the findings are mainly from male participants and the aberrant effects in autism spectrum disorder females and sex differences are still unclear. To address these issues, this study analyzed intrinsic functional connectivity of mentalizing regions using resting-state functional magnetic resonance imaging data of 48 autism spectrum disorder males and females and 48 typically developing participants in autism brain imaging data exchange. Whole-brain analyses showed that autism spectrum disorder males had hyperconnectivity in functional connectivity of the bilateral temporal-parietal junction, whereas autism spectrum disorder females showed hypoconnectivity in functional connectivity of the medial prefrontal cortex, precuneus, and right temporal-parietal junction. Interaction between sex and autism was found in both short- and long-distance functional connectivity effects, confirming that autism spectrum disorder males showed overconnectivity, while autism spectrum disorder females showed underconnectivity. Furthermore, a regress...Continue Reading

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Citations

May 28, 2019·Medical & Biological Engineering & Computing·Paula G RodriguesDiogo C Soriano
Apr 27, 2019·Frontiers in Neuroscience·Nina de LacyVince D Calhoun
Mar 14, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Christopher HammillMeng-Chuan Lai
Jul 18, 2021·Journal of Autism and Developmental Disorders·Vânia TavaresDiana Prata

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Methods Mentioned

BETA
SMA

Software Mentioned

Analyses of Functional NeuroImages ( AFNI )
ABIDE
ADOS
SOCIAL
3dClustSim

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