Different actions of CCK on pancreatic and gastric growth in the rat: effect of CCK(A) receptor blockade

British Journal of Pharmacology
G VargaC Scarpignato

Abstract

1. It is now well established that cholecystokinin (CCK) has a major physiological role in the regulation of pancreatic secretion and gastro-intestinal (GI) motility. Both these actions are mediated by stimulation of CCK(A)-receptors located on pancreatic acini and GI smooth muscle cells. While chronic administration of CCK-like peptides invariably causes pancreatic hypertrophy and hyperplasia, their action on gastric growth remains controversial. 2. In the present investigation the action of exogenous and endogenous CCK on both pancreatic and gastric growth was studied in the same animal. In addition, the ability of dexloxiglumide, a new potent and selective CCK(A)-receptor antagonist, to counteract CCK-mediated effects was evaluated. 3. The amphibian peptide caerulein (1 microg kg(-1) intraperitoneally three times daily) was used as a CCK agonist, while camostate (200 mg kg(-1) intragastrically once daily), a synthetic protease inhibitor, was used to release endogenous CCK. They were administered to rats for seven days with or without dexloxiglumide (25 mg kg(-1) subcutaneously 15 min before the stimulus). On the eighth day, animals were killed, the pancreas and stomach excised, weighed, homogenized and their protein and DNA ...Continue Reading

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Citations

Apr 13, 2000·Journal of Physiology, Paris·K KordásG Varga
Sep 23, 2003·Journal of Pharmaceutical Sciences·Sanna Tolle-SanderJames E Polli
Apr 22, 2004·British Journal of Pharmacology·Gábor VargaMassimo D'Amato
Feb 24, 2001·Japanese Journal of Pharmacology·K YoshinagaY Segawa
May 16, 2006·Digestive Diseases·Shajan A S PeterChristoph Beglinger
Sep 6, 2007·Ultrastructural Pathology·E C SeretisI E Voloudakis-Baltatzis
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katsuhiko YoshizawaAbraham Nyska
Mar 29, 2002·Clinics in Perinatology·Douglas G Burrin, Barbara Stoll

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