PMID: 2122744Nov 1, 1990Paper

Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries

The American Journal of Physiology
V RichardT F Lüscher

Abstract

Endothelial cells release nitric oxide from L-arginine, and this pathway can be inhibited by the analogue of L-arginine, NG-monomethyl-L-arginine (L-NMMA). The effect of L-NMMA on endothelium-dependent relaxation of epicardial porcine coronary arteries was studied in isolated blood vessels suspended in organ chambers for isometric tension recording. Endothelium-dependent relaxations to bradykinin, serotonin, and the alpha 2-adrenergic agonist clonidine were evaluated in the presence and absence of L-NMMA (10(-5)-10(-3) M). L-NMMA, as well as the inhibitor of guanylate cyclase methylene blue (10(-5) M) and hemoglobin (10(-5) M), inhibited endothelium-dependent relaxation to serotonin and clonidine. The effect of L-NMMA could be reversed by L-arginine but not by D-arginine. In contrast, L-NMMA, methylene blue, and hemoglobin caused a weak inhibition of the endothelium-dependent relaxation evoked by bradykinin; indomethacin and tranylcypromine had no effect. The inhibitor of Gi proteins pertussis toxin (100 ng/ml) abolished the relaxations evoked by clonidine and markedly reduced those evoked by serotonin but did not affect those caused by bradykinin. In the presence of pertussis toxin, L-NMMA induced a further reduction of the re...Continue Reading

Citations

Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N R Searle, P Sahab
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A P Zou, A W Cowley
May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ana Paula V DantasThomas Michel
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Q YangS T O'Rourke
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca W CarterNancy L Kanagy
Sep 13, 2001·American Journal of Physiology. Renal Physiology·C F Plato, J L Garvin
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo KobayashiKatsuo Kamata
Sep 10, 1998·Journal of Veterinary Pharmacology and Therapeutics·Y NakamuraA Nishio
May 1, 1994·The American Journal of the Medical Sciences·R S Meidell

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