Different allele-distribution of mthfr 677 C -> T and mthfr -393 C -> a in patients classified according to subtypes of Lesch's typology

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Dominikus BönschStefan Bleich

Abstract

The typology by Lesch distinguishes between four subtypes: type 1 (model of allergy), type 2 (model of anxiety or conflict), type 3 (alcohol as an antidepressant), and type 4 (alcohol as adaptation). Taking into account that alcohol dependence is associated with elevated homocysteine levels, this study was undertaken to investigate different MTHFR (methylenetetrahydrofolate reductase) genotypes related to homocysteine metabolism in patients with alcohol dependence who were classified according to Lesch's typology (LT). 134 non-abstinent chronic alcoholics (112 males, 22 females; mean age 44.2 (SD 8.9) years) were classified according to LT and divided into four groups: LT 1 (n = 26), LT 2 (n = 65), LT 3 (n = 58), and LT 4 (n = 18). Total plasma homocysteine levels and MTHFR genotypes -393, 677, and 1,793 were determined. We observed a significantly higher frequency of the thermolabile MTHFR 677 C-->T variant (TT) in patients classified as subtype LT4 when compared with subtypes LT2 and LT3 (P = 0.005). Furthermore, for the MTHFR -393 C --> A-polymorphism, significantly more AC/AA variants were found in subtype LT4 (P = 0.034). No differences in allele-distribution were detected for MTHFR 1793. To our knowledge, this is the firs...Continue Reading

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Citations

Aug 12, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Maria da Penha Zago-Gomes, Ester Miyuki Nakamura-Palacios
Feb 3, 2009·Neuropsychology Review·Lorenzo LeggioRobert M Swift
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Jul 26, 2011·The International Journal of Neuropsychopharmacology·Ester Miyuki Nakamura-PalaciosFelipe Fregni
May 21, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Darshana MirgalShrimati Shetty

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