Different antibiotic regimes in men diagnosed with lower urinary tract infection - a retrospective register-based study.

Scandinavian Journal of Primary Health Care
Helena Kornfält IsbergAnders Beckman

Abstract

To compare the proportion of therapy failure, recurrence and complications within 30 days after consultation between men diagnosed with lower urinary tract infection (UTI) treated with narrow-spectrum antibiotics (nitrofurantoin or pivmecillinam) and broad-spectrum antibiotics (fluoroquinolones or trimethoprim or trimethoprim/sulfamethoxazole). A retrospective cohort study based on data derived from electronic medical records between January 2012 and December 2015. Primary health care and hospital care in five different counties in Sweden. Patients: A total of 16,555 men aged between 18 and 79 years diagnosed with lower UTI. Treatment with narrow-spectrum antibiotics was compared with broad-spectrum antibiotics regarding therapy failure, recurrence and complications within 30 days. The median age of included men was 65 IQR (51-72) years. Narrow-spectrum antibiotics were prescribed in 8457 (40%) and broad-spectrum antibiotics in 12,667 (60%) cases, respectively. Therapy failure was registered in 192 (0.9%), recurrence in 1277 (6%) and complications in 121 (0.6%) cases. Therapy failure and recurrence were more common in patients treated with narrow-spectrum antibiotics and trimethoprim (p < 0.001), but no such difference could be...Continue Reading

References

Apr 11, 2003·Scandinavian Journal of Infectious Diseases·Peter Ulleryd, Torsten Sandberg
Sep 22, 2009·Clinics in Geriatric Medicine·L E Nicolle
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalpana GuptaUNKNOWN European Society for Microbiology and Infectious Diseases
Oct 18, 2011·International Journal of Antimicrobial Agents·Kurt G NaberFlorian M E Wagenlehner
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Oct 22, 2014·JAMA : the Journal of the American Medical Association·Larissa GrigoryanKalpana Gupta
Oct 9, 2015·Therapeutic Advances in Urology·Michelle L IngalsbeKari A Mergenhagen
Feb 11, 2016·The New England Journal of Medicine·Anthony J Schaeffer, Lindsay E Nicolle

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