Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells

Food & Function
Qiu WuXingbin Yang

Abstract

This study was designed to investigate the tumor-inhibitory effects of quercetin (Que) and its water-soluble metabolites, quercetin-3'-sulfate (Q3'S) and quercetin-3-glucuronide (Q3G), as well as to make the molecular mechanism and structure-antitumor relationship clear. It was found that Que, Q3'S, and Q3G could inhibit the growth of human breast cancer MCF-7 cells in a dose-dependent manner, with the IC50 values of 23.1, 27.6, and 73.2 μM, respectively, and their anticancer effect was ranked as Que > Q3'S > Q3G. Furthermore, flow cytometric assay revealed that Que, Q3'S, and Q3G mediated the cell-cycle arrest principally at the S phase and decreased the number of G0/G1 and G2/M after a 48 h treatment with human breast MCF-7 cells. Moreover, it was found that 70.8%, 58.2%, and 48.0% of MCF-7 cancer cells entered the early phase of apoptosis when treated with 100 μM Que, Q3'S, and Q3G for 48 h, respectively. In addition, induction of apoptosis by Que, Q3'S, and Q3G was accompanied by marginal generation of intracellular reactive oxygen species (ROS) in the MCF-7 cancer cells. Overall, these results demonstrate that Que, Q3'S, and Q3G possess strong antitumor effects through induction of an ROS-dependent apoptosis pathway in MCF...Continue Reading

References

Dec 19, 2000·Free Radical Biology & Medicine·A J DayG Williamson
Mar 31, 2004·Cellular and Molecular Life Sciences : CMLS·P M Jones, A M George
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Jiri BartekJiri Lukas
Sep 23, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jirapan MoungjaroenYon Rojanasakul
Jul 3, 2008·Journal of Agricultural and Food Chemistry·O Benavente-García, J Castillo
Oct 18, 2008·The Journal of Nutritional Biochemistry·Ching-Han YuPaulus S Wang
Feb 3, 2009·Journal of Agricultural and Food Chemistry·Susana González-ManzanoMontserrat Dueñas
May 19, 2010·International Journal of Molecular Sciences·Massimo D'ArchivioRoberta Masella
Aug 5, 2010·Journal of Agricultural and Food Chemistry·Hyeong-Jin KimJi-Youn Jung
Oct 7, 2010·Journal of Agricultural and Food Chemistry·Sara JaramilloFrancisco J G Muriana
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 10, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S SreelathaP R Padma
Nov 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Parisa Fathi RezaeiEbrahim Azizi
Feb 9, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haisheng ZhangXingbin Yang
Jan 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanmang CuiYan Zhao
May 30, 2014·The Lancet Oncology·Lei FanPaul E Goss
Feb 19, 2015·European Journal of Nutrition·Shu-Lan YehCheng-Hung Chuang
Jan 17, 2016·Annual Review of Food Science and Technology·Mary Ann LilaWilhelmina Kalt

❮ Previous
Next ❯

Citations

Sep 26, 2019·Journal of Food Science·Francisco Rodríguez-FélixJosé Agustín Tapia-Hernández
Dec 28, 2019·BioFactors·Erfan TavanaAmirhossein Sahebkar
Nov 23, 2019·Inflammopharmacology·Neda KasiriHossein Motedayyen
Dec 14, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hasene Mutlu GençkalFerda Ari
Jul 21, 2020·Journal of Food Biochemistry·Amirhossein DavoodvandiSadegh Jafarnejad
Aug 14, 2020·International Journal of Molecular Sciences·María Ángeles Ávila-GálvezAntonio González-Sarrías
Sep 28, 2020·Medicinal Research Reviews·Junmin ZhangJianguo Fang
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danielly C Ferraz da CostaEliane Fialho
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAsma Ismail Mahmod
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tae Heon KimDae Kyun Chung
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini Sundramurthi ChelliahIshwar Parhar
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marco BonesiRosa Tundis
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sang Hee ParkJae Youl Cho

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry
fluorescence microscopy
Fluorescence

Software Mentioned

SPSS
Origin

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.