PMID: 8614236Mar 3, 1995Paper

Different atypical beta-adrenoceptors mediate isoprenaline-induced relaxation in vascular and non-vascular smooth muscles

Life Sciences
M A Oriowo

Abstract

Atypical beta-adrenoceptors mediating smooth muscle relaxation were compared in several rat tissues including the distal colon, fundic strip, thoracic aorta and common carotid artery. Isoprenaline, CGP 12177 and BRL 37344 concentration-dependently relaxed longitudinal strips of the distal colon and fundus precontracted with carbachol (10(-6)M) as well as ring segments of the aorta and carotid artery precontracted with noradrenaline (10(-7)M). The rank order of potency was isoprenaline = BRL 37344 > CGP 12177 in the distal colon, isoprenaline = CGP 12177 > BRL 37344 in the aorta and carotid artery segments and isoprenaline > BRL 37344 > CGP 12177 in the fundic strip. Pretreatment with BRL 37344 induced a marked desensitization of the distal colon and fundic strips but not the aorta and carotid artery to isoprenaline. In the fundus and distal colon, pretreatment with CGP 12177 (10(-4)M abolished the effect of isoprenaline. Cyanopindolol (10(-6)M) shifted the isoprenaline curve to the right, without reducing the maximum response, in the distal colon fundic strip. -logKB values were 7.44 +/- 0.08 and 7.53 +/- 0.10 in the distal colon and fundic strip respectively. The same concentration of cyanopindolol did not inhibit the relaxant...Continue Reading

Citations

Dec 9, 2003·European Journal of Pharmacology·Mayumi MatsushitaKatsuo Koike
Dec 21, 2000·Trends in Pharmacological Sciences·C GauthierJ L Balligand
Feb 28, 2003·Ageing Research Reviews·William E Schutzer, Scott L Mader
Aug 24, 1999·British Journal of Pharmacology·P A Longhurst, M Levendusky
Feb 22, 2000·British Journal of Pharmacology·L BrawleyA MacDonald
Oct 8, 1999·Journal of Autonomic Pharmacology·A MacDonaldA M Shaw
May 5, 1999·Fundamental & Clinical Pharmacology·M A Oriowo, O Thulesius
Sep 10, 2005·British Journal of Pharmacology·Agnieszka ZakrzeskaBarbara Malinowska
Jun 29, 2001·Acta Physiologica Hungarica·M ShafieiM Mahmoudian
Jul 8, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·O A López-CanalesB Escalante
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Valery I KozlovskiRichard J Gryglewski
Jan 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·Cleber E TeixeiraGilberto De Nucci
Aug 15, 1998·Biochemical and Biophysical Research Communications·J TamaokiA Nagai

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