Different behaviour of BK-virus infection in liver transplant recipients

World Journal of Gastroenterology : WJG
I UmbroA P Mitterhofer

Abstract

Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patients, asymptomatic BKV viremia and/or viruria can be observed. Renal grafts may also be sources of infection as BKV prefers kidneys rather than other solid organs for transplantation such as the liver. The mechanism behind the higher incidence of BKV infection in kidney transplant patients, compared to liver or heart transplantation, is unclear and the prevalence of BKV infection in non-renal solid organ transplants has not been yet thoroughly investigated. We evaluated the prevalence of Polyomavirus BK infection among liver transplant recipients. A PubMed search was conducted using the terms BKV infection AND liver transplant recipients; BKV AND non-renal solid organ transplant*; BKV infection AND immunosuppression; the search was limited to title/abstract and English-language articles published from 2000, to March 2015. Eleven relevant studies suggest that the prevalence of BKV viruria and/or viremia among liver t...Continue Reading

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Citations

May 26, 2017·Current Opinion in Organ Transplantation·Stephanie G YiKeri E Lunsford
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Mar 5, 2021·Annals of Hematology·Małgorzata Salamonowicz-BodziochJan Styczyński
Jul 25, 2021·Pediatric Transplantation·Dorna DerakhshanSahand Mohammadzadeh

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BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.