Different brain areas are involved in memory expression at different times from training

Neurobiology of Learning and Memory
J A QuillfeldtI Izquierdo

Abstract

Rats were trained in a step-down inhibitory avoidance task and tested for retention 1, 31, or 60 days later. Three to 7 days prior to testing, they were bilaterally implanted with cannulae in the CA1 region of the dorsal hippocampus and in the amygdaloid nucleus (H + A), in the entorhinal cortex (EC), and in the posterior parietal cortex (PPC). Ten minutes prior to testing, the animals received, through the cannulae, 0.5-microliter microinfusions of vehicle (20% dimethylsulfoxide in saline) or of 0.5 microgram of CNQX dissolved in the vehicle. A second test session was carried out 90 min after the first. CNQX blocked retention test performance when given into H + A 1 day after training but not later; when given into EC 1 or 31 days after training, but not later; and when given into PPC 1, 31, or 60 days after training. In all cases performance returned to normal levels in the second test session. The data suggest that H and A are involved in memory expression for only a few days after acquisition; that EC is involved in memory expression for up to 31, but less than 60, days after acquisition; and that PPC is involved in memory expression for up to at least 2 months after acquisition.

Citations

Nov 30, 2011·Behavioral Neuroscience·Benno Roozendaal, James L McGaugh
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Jan 12, 2010·Neuropeptides·Mayra Tolentino Resk LemosHudson Sousa Buck
Apr 1, 2008·Behavioural Brain Research·Jorge H MedinaIván Izquierdo
Nov 29, 2011·Hippocampus·Lucas de Oliveira AlvaresJorge Alberto Quillfeldt
Mar 4, 2014·Neurobiology of Learning and Memory·Erno J HermansBenno Roozendaal
Nov 13, 2013·NeuroImage·Carly C G SweegersLucia M Talamini
Feb 11, 2016·Hippocampus·Josue HaubrichJorge Alberto Quillfeldt
Sep 27, 2005·Physiology & Behavior·Eduardo Ekman SchenbergMaria Gabriela Menezes Oliveira
Aug 22, 2006·Hippocampus·Loren M FrankGarrett B Stanley
Oct 27, 2006·Journal of Neural Transmission·E L Schaeffer, W F Gattaz
Jul 5, 2018·Nature Reviews. Neuroscience·Susumu TonegawaTakashi Kitamura

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