Different Ca2+ affinities and functional implications of the two synaptic adhesion molecules cadherin-11 and N-cadherin

Molecular and Cellular Neurosciences
W M HeupelNikola Golenhofen

Abstract

Cadherins of synaptic complexes are considered to be critically involved in long-term potentiation (LTP). Here we compared biophysical properties of cadherin-11 and N-cadherin, which appear to exert opposing effects on LTP, i.e., inhibition and promotion, respectively. Characterization of cadherin-11 binding by atomic force microscopy and laser tweezers revealed a significantly higher Ca(2+) affinity, with half-maximal binding (K(D)) at 0.11-0.26 mM Ca(2+), as compared to N-cadherin (K(D) approximately 0.7 mM Ca(2+)). Adhesive properties of both cadherins were modulated to a similar degree by manipulation of the actin cytoskeleton indicating to unlikely account for opposing roles in LTP induction. However, differences in Ca(2+) affinity could well explain opposing binding properties during activity-dependent transient reduction of extracellular Ca(2+) ([Ca(2+)](e)) in the synaptic cleft: whereas high frequency stimulation with drop of [Ca(2+)](e) to 0.3-0.8 mM Ca(2+) will result in significant weakening of N-cadherin adhesion, cadherin-11-based adhesion will stay mostly stable. Reduction of N-cadherin adhesion may facilitate synaptic remodeling and LTP induction, while cadherin-11 adhesion with its higher stability at low [Ca(2...Continue Reading

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Citations

Jul 27, 2011·Journal of Molecular Neuroscience : MN·Lars DolgeWerner Baumgartner
Sep 1, 2009·The Journal of Biological Chemistry·Volker SpindlerJens Waschke
Nov 20, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Joshua D HutchesonW David Merryman
Jan 22, 2011·Cell Communication & Adhesion·Britta Bartelt-KirbachNikola Golenhofen
Jul 8, 2008·Current Opinion in Cell Biology·Chin-Yin TaiErin M Schuman
Jan 13, 2015·Metallomics : Integrated Biometal Science·E HeiligerW Baumgartner
Feb 17, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Hiroko SugiuraKanato Yamagata
Mar 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicolas SchlegelJens Waschke
Sep 21, 2018·Frontiers in Molecular Neuroscience·Christoph WolfWerner Baumgartner

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