Different cabergoline effect on metabolic and anthropometric parameters in female prolactinoma patients versus idiopathic hyperprolactinemia patients

Endocrine, Metabolic & Immune Disorders Drug Targets
Mohamed M AboelnagaMostafa El Shaer

Abstract

We aimed in the current study to: 1) evaluate and compare metabolic and anthropometric profile in female patients with newly diagnosed prolactin secreting adenoma versus female idiopathic hyperprolactinemic patients 2) compare the effects of one year cabergoline therapy on the metabolic profile and anthropometric parameters (by using visceral adiposity index as index for evaluation of adipose tissue dysfunction) in female patients with prolactin secreting pituitary adenoma to female idiopathic hyperprolactinemic patients. We enrolled 40 female patients with newly diagnosed prolactin-secreting pituitary adenoma (29 patients with micro adenoma and 11 patients with macro adenoma) and 40 female patients with idiopathic hyperprolactinemia, who were matched according to: age; weight; BMI; waist; and prolactin levels. The participants were enrolled in this study at the time of diagnosis before therapy. The patients were followed up during therapy with cabergoline for 12 months. 12 months Cabergoline therapy had statistically significant favorable effect lipid, metabolic and VAI in all patients. Also 12 months of CAB therapy was statistically significant more effective as regard BMI, waist circumference, HDLc and VAI in patient with id...Continue Reading

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