Different calorie restriction treatments have similar anti-seizure efficacy

Seizure : the Journal of the British Epilepsy Association
Andrea ViggianoGiangennaro Coppola

Abstract

Previous studies showed that a single oral administration of a synthetic ketone ester (1,3-butanediol acetoacetate diester, BD-AcAc2) could elevate blood ketones with promising acute anti-epileptic effects. The aim of the present work was to evaluate the tolerability of a prolonged administration of BD-AcAc2 and the anti-epileptic efficacy of such treatment. The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats after a ten-day oral administration of BD-AcAc2 (gavage). The effects of this treatment were compared to those of: (1) a ten-day water gavage administration, (2) a ten-day ketogenic diet, (3) a standard rodent chow diet. Compared to the standard diet, all other treatments produced a calorie restriction and an elevation of the seizure threshold. These results indicate that supplementation with an oral synthetic ketone can have anti-seizure effects, but the formulation has to be further ameliorated to be more palatable; further studies are also needed to better understand the role played by ketone bodies alone in vivo, without any calorie restriction.

References

Jun 24, 2004·Journal of Neuroscience Research·Clara M ChengCarolyn A Bondy
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Mar 25, 2014·Epilepsy & Behavior : E&B·Alan W C Yuen, Josemir W Sander
Jun 1, 2015·Brain Research·Andrea ViggianoGiangennaro Coppola

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Citations

Apr 12, 2017·Neurochemical Research·Timothy A SimeoneJong M Rho
Jan 13, 2018·Neuropharmacology·Timothy A SimeoneJong M Rho

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