Different carcinogenesis in the gastric remnant after gastrectomy for gastric cancer

Cancer
M KaminishiT Oohara

Abstract

The incidence of gastric remnant cancer after surgery for gastric malignancies has been increasing. The interval between previous operations and the diagnosis of gastric remnant cancer, location of cancer development, and histologic type were different from those after surgery for benign diseases. However, very little is known about the reasons for these differences. Patients with gastric cancer already have cancer-related gastric mucosal changes at gastrectomy, and they undergo a wide range of dissection of nerve distribution to the stomach due to lymph node dissection. Therefore, the effects of preliminary administration of a carcinogenic agent and denervation of the gastric mucosa on tumorigenesis in the gastric remnant were investigated. Using male Wistar rats, N-methyl-N'-nitro-N-nitroguanidine (MNNG; 50 mg/L) was given in drinking water for 10 weeks. The animals were then assigned into four groups of those undergoing Billroth I (B-I) gastrectomy or Billroth II (B-II) gastrectomy, with and without denervation. Subdiaphragmatic truncal vagotomy was performed in the denervated group. Thirty weeks after gastrectomy, the following investigations were performed: histologic examination and periodic acid-Schiff-Alcian blue (PAS-A...Continue Reading

References

Aug 1, 1975·Cancer·T IwanagaA Wada
Jan 1, 1992·American Journal of Surgery·D W MercerD T Dempsey
Dec 1, 1987·Cancer Letters·P M NewberneT F Schrager
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Citations

Aug 10, 2004·World Journal of Gastroenterology : WJG·Christian KirschStephan Miehlke
Oct 21, 2006·The British Journal of Surgery·M OhashiM Sasako
Jan 1, 1997·Journal of Clinical Gastroenterology·M KaminishiM Tatematsu

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