Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study

Scientific Reports
Cui-Qin SangZhen-Yu Zhang

Abstract

The aim was to evaluate the efficacy and safety of different combination strategies for prophylaxis of venous thromboembolism (VTE) after gynecologic surgery in patients at different levels of risk. This was a prospective multicenter randomized controlled study, in which 625 women who would undergo pelvic surgery for gynecologic diseases were stratified into three risk groups and then randomized into four groups to receive graduated compression stockings (GCS) alone (group A), GCS + low molecular weight heparin (LMWH) (group B), GCS + intermittent pneumatic compression (IPC) (group C), and GCS + IPC + LMWH (group C), respectively. The overall incidence of DVT was 5.1%. Group A had the highest incidence of DVT (8.8%), followed by group C (5.2%), group B (3.8%), and group D (2.6%). There was a significant difference in the incidence of DVT between groups A and D. The incidence of DVT was significantly lower in LMWH-treated patients (group B + group D) than in non-LMWH-treated patients (group A + group C). In conclusion, combination prophylaxis, especially LMWH-containing strategies, is better than monoprophylaxis in reducing VTE after gynecologic surgery. Risk-stratified prophylactic strategies should be implemented in patients u...Continue Reading

References

Mar 1, 1983·American Journal of Obstetrics and Gynecology·D L Clarke-PearsonW T Creasman
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Nov 24, 2004·Australian Journal of Midwifery : Professional Journal of the Australian College of Midwives Incorporated·Pauline Glover
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Mar 2, 2006·Obstetrics and Gynecology·Martin A MartinoMitchel S Hoffman
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Dec 5, 2009·BMJ : British Medical Journal·Siân SweetlandUNKNOWN Million Women Study collaborators
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Nov 29, 2016·Gynecologic Oncology·Emma L Barber, Daniel L Clarke-Pearson

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Citations

Dec 15, 2020·The Medical Journal of Australia·Esther Mc JohnsPavitra Nanayakkara
Oct 12, 2020·American Journal of Obstetrics and Gynecology·Janelle K MoulderMichelle Louie
Apr 21, 2021·Revista colombiana de obstetricia y ginecología·Grupo Desarrollador Del Consenso De Tromboprofilaxis En Cirugía Ginecológica, Federación Colombiana de Obstetricia Y Ginecología Fecolsog
Aug 14, 2021·Knee Surgery & Related Research·Satit ThiengwittayapornUNKNOWN Asia-Pacific (AP) Region Venous Thromboembolism (VTE) Consensus Group
Jan 29, 2022·The Cochrane Database of Systematic Reviews·Stavros KakkosDaniel J Reddy

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