PMID: 18709951Aug 20, 2008Paper

Different concentrations of clarithromycin ophthalmic gel for rabbits corneal ulcers induced by Staphylococcus aureus

Yan ke xue bao = Eye science
Jianming WangNaixue Sun

Abstract

To screen proper concentration of clarithromycin ophthalmic gel by observing the efficacy of different concentrations of clarithromycin ophthalmic gel for treating staphylococcal corneal ulcers. Corneal ulcer was induced in the right eye of 40 rabbits, 3.0 x 10(9) CFU/ml staphylococcus aureus suspension was injected midstromally into the central corneal. These rabbits were divided randomly into 5 groups, each group received respectively topical blank matrix, clarithromycin ophthalmic gel 0.1%, clarithromycin ophthalmic gel 0.25%, levofloxacin ophthalmic gel, clarithromycin ophthalmic gel 0.25% and recombinant bovine basic fibroblast growth factor (Rb-bFGF), 4 times every day, 2 drops each time. The eyes were examined respectively with the slit lamp before treatment (day 0), on day 3, day 5, day 7, day 10, day 14 to observe the progression of corneal ulceration, including the area of the corneal ulcer and mark of keratitis. Under the same way of giving medicine, experimental corneal ulcer studies showed a statistically significant decrease in all treatment groups on measurements of the area of the corneal ulcer and mark of keratitis (P < 0.05), and clarithromycin ophthalmic gel 0.25% had a better action than clarithromycin ophth...Continue Reading

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