Different contributions of side-chains in beta-D-(1-->3,6)-galactans on intestinal Peyer's patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge

Phytochemistry
Hiroaki KiyoharaHaruki Yamada

Abstract

Thirteen polysaccharides isolated from an extract of the aerial portions of Astragalus mongholics Bunge demonstrated immunomodulating activity against Peyer's patch immunocompetent cells. Nine of the active polysaccharide fractions were composed of either arabinogalactans, pectic arabinogalactans or pectins. The activities of the arabinogalactans and pectic arabinogalactans were associated with beta-D-(1-->3)-galactan moieties branched with beta-D-(1-->6)-galactooligosaccharide side-chains having degrees of polymerization of 8 or less. Degradation of the beta-D-(1-->3)-galactan or beta-D-(1-->6)-galactosyl side-chains in the arabinogalactans significantly decreased immunomodulating activity. Rhamnogalacturonan I (RG-I) with beta-D-(1-->3,6)-galactosyl side-chains having terminal beta-D-GlcA showed activity in the pectin-enriched fractions. Interestingly, the terminal GlcA was not required for activity of the arabinogalactan-enriched fractions, suggesting at least two different immunomodulating structures.

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Citations

Sep 10, 2013·Biochemistry. Biokhimii︠a︡·S V Popov, Yu S Ovodov
Dec 29, 2013·International Journal of Biological Macromolecules·Xue-Qiang ZhaJian-Ping Luo
Jun 19, 2013·Chemistry & Biodiversity·Li-Peng YangJian-Qin Jiang
Dec 15, 2010·Biomedical Chromatography : BMC·Yong-gang XiaHai-xue Kuang
Apr 30, 2013·International Journal of Biological Macromolecules·Anton SlavovHaruki Yamada
Apr 26, 2016·The American Journal of Chinese Medicine·Rui JiaoKwok Fai So
Feb 27, 2016·The American Journal of Chinese Medicine·Kathy K AuyeungJoshua K Ko
Apr 20, 2019·International Journal of Molecular Sciences·Hao ShanMin Li
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Feng ZouZhong-Qiong Yin
Apr 9, 2020·Frontiers in Pharmacology·Yijun ZhengYongqi Liu

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