Different cytogenetic patterns in skeletal breast cancer metastases

Genes, Chromosomes & Cancer
A AdeyinkaF Mitelman

Abstract

Short-term cultures of breast cancer metastases to bone from two patients were analyzed cytogenetically. One metastasis had a complex hypotriploid karyotype with numerous marker chromosomes, whereas the other had simple karyotypic changes in three unrelated clones, 46,XX,t(4;11 )(p14;p 13)/45,XX,- 19/46,XX,del(3)(p 13p23), suggesting that the metastasis had originated from a simultaneous invasion of multiple cells from the primary tumor. The metastasis with complex chromosomal aberrations developed quickly as part of a clinically aggressive disease, whereas that with simple changes developed more than 20 years after the initial breast cancer diagnosis. Our findings therefore indicate that the tumor karyotype may play a role in determining the clinical course in patients with breast cancer.

References

Jul 1, 1992·Genes, Chromosomes & Cancer·N PandisF Mitelman
Mar 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O S NielsenI F Tannock
Dec 1, 1994·Genes, Chromosomes & Cancer·F MertensN Mandahl
Jul 1, 1993·Cancer Genetics and Cytogenetics·M TarkkanenS Knuutila

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Citations

Dec 18, 2001·Genes, Chromosomes & Cancer·Manuel R TeixeiraSverre Heim
Jun 12, 2012·Cancer Metastasis Reviews·Jinchun Yan, Qihong Huang
May 1, 1997·Cancer Genetics and Cytogenetics·S HeimN Pandis
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Andreas SchneeweissAlwin Krämer

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