Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI

Developmental Neuroscience
Chao TangJingxin Nie

Abstract

There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are significant differences in the developmental patterns of local and global brain activities between ADHD and typically developing (TD) individuals. Three voxel-based measurements and the functional connectivity (FC) of the brain networks were extracted from resting-state functional magnetic resonance imaging (fMRI) of both ADHD and TD participants 7-16 years of age. The topological properties of brain networks in both groups were also analyzed, including hubs, hemispheric symmetry, together with local and global efficiency. The results showed, from the local perspective, that the ADHD group had abnormal amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, and regional homogeneity in the medial orbital frontal cortex, anterior cingulate cortex, postcentral gyrus, thalamus, precuneus, and cerebellum compared with the TD group. From the global perspective, the aberrant FC between m...Continue Reading

Associated Clinical Trials

Citations

May 10, 2020·European Child & Adolescent Psychiatry·Stefano DamianiPierluigi Politi
Oct 24, 2019·Journal of Attention Disorders·Doug Hyun HanPerry Renshaw

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