PMID: 9167213Apr 1, 1997Paper

Different effects of a thromboxane mimetic on blood flow and plasma exudation in guinea pig airways and skeletal muscle

Prostaglandins
Z H CuiJ Lötvall

Abstract

Thromboxane A2 (TXA2) is a potent constrictor of both airway and vascular smooth muscle. In addition, plasma exudation is induced in the airways by a thromboxane mimetic (U-46619). Because plasma exudation is associated with a local vasodilatation and increased local blood flow, we hypothesized that the general vasoconstrictor effect of U-46619 would be weaker in the airways than in other vascular beds, perhaps resulting in increased local airway blood flow. We studied the effects of i.v. U-46619 on blood pressure, lung resistance as well as blood flow, plasma exudation in airways and leg skeletal muscle in guinea pigs. We found (1) i.v. U-46619 increases the systemic blood pressure, blood flow in tracheal mucosa but decreases blood flow in leg skeletal muscle; (2) i.v. U-46619 induces plasma exudation in the airways, but not in the leg skeletal muscle; (3) a positive relationship between blood pressure and tracheal blood flow as well as airway plasma exudation, a negative relationship between blood pressure and blood flow in leg skeletal muscle; (4) i.v. U-46619 significantly increases lung resistance. We conclude that i.v. U-46619 induces plasma exudation in airways but not in skeletal muscle, and that this plasma exudation i...Continue Reading

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Citations

Dec 26, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stéphane DragonAbdelilah Soussi Gounni
Jun 5, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shahina Wiehler, David Proud

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