PMID: 9557928Apr 29, 1998Paper

Different effects of calcium antagonists on fluid filtration of large arteries and albumin permeability in spontaneously hypertensive rats

Journal of Hypertension
P LacolleyB I Levy

Abstract

To compare the effects of chronic administration of two dihydropyridines, nifedipine and amlodipine, and the non-dihydropyridine Ca2+ antagonist mibefradil on fluid filtration of large arteries and extravasation of albumin in spontaneously hypertensive rats. Spontaneously hypertensive rats aged 2 months were randomly allocated to oral treatment once a day with 30 mg/kg mibefradil (n=12), 100 mg/kg nifedipine (n=12), 20 mg/kg amlodipine (n=12) or placebo (n=12) for 1 month. Instantaneous blood pressure of rats under pentobarbital anaesthesia was recorded at the end of the treatment Fluid filtration across the carotid arterial wall was determined in situ in the isolated carotid artery. Extravasation of 25 mg/kg Evans Blue dye that had been injected intravenously was used to assess whole vascular permeability to albumin after chronic treatment with mibefradil. Similar reductions in mean arterial pressure were obtained in all Ca2+ antagonist-treated rats. Heart rate was similar in rats in control, nifedipine and amlodipine groups but was significantly lower in mibefradil-treated rats (by 19%, P< 0.001). Fluid filtration across the carotid wall was greater in all Ca2+ antagonist-treated animals. However, fluid filtration was signifi...Continue Reading

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Citations

Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Suin YoonInho Jo
Sep 15, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Inho JoSangmee Ahn Jo
Feb 25, 2005·The Annals of Pharmacotherapy·Didem SenerServet Arioğul
May 12, 2001·Journal of Cardiovascular Pharmacology·M B AndrésdóttirF T Huysmans

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