Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors

Frontiers in Cellular Neuroscience
Adriana BajettoTullio Florio

Abstract

Glioblastoma (GBM), the most common primary brain tumor in adults, is an aggressive, fast-growing and highly vascularized tumor, characterized by extensive invasiveness and local recurrence. In GBM and other malignancies, cancer stem cells (CSCs) are believed to drive invasive tumor growth and recurrence, being responsible for radio- and chemo-therapy resistance. Mesenchymal stem cells (MSCs) are multipotent progenitors that exhibit tropism for tumor microenvironment mediated by cytokines, chemokines and growth factors. Initial studies proposed that MSCs might exert inhibitory effects on tumor development, although, to date, contrasting evidence has been provided. Different studies reported either MSC anti-tumor activity or their support to tumor growth. Here, we examined the effects of umbilical cord (UC)-MSCs on in vitro GBM-derived CSC growth, by direct cell-to-cell interaction or indirect modulation, via the release of soluble factors. We demonstrate that UC-MSCs and CSCs exhibit reciprocal tropism when co-cultured as 3D spheroids and their direct cell interaction reduces the proliferation of both cell types. Contrasting effects were obtained by UC-MSC released factors: CSCs, cultured in the presence of conditioned medium (...Continue Reading

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Citations

Aug 20, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Mona N OliveiraTamara T Lah
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Abdelkrim HmadchaVivian Capilla-Gonzalez
Nov 11, 2018·Stem Cell Research & Therapy·Lorena Favaro PavonSérgio Cavalheiro
Jun 17, 2020·Stem Cells Translational Medicine·Adriana BajettoTullio Florio
Oct 22, 2020·International Journal of Molecular Sciences·Deborah PietrobonoMaria Letizia Trincavelli
Jan 14, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Micheli Mainardi PillatHenning Ulrich
Jul 3, 2021·Cancers·Ruth M UrbantatSusan Brandenburg
Nov 19, 2021·Journal of Hematology & Oncology·Tianxia LanXiawei Wei

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Methods Mentioned

BETA
surgical resection
mechanical dissociation
FACS
Assay
PCR
confocal microscopy
flow cytometry
antibody array

Software Mentioned

ModFit analysis
One
FACSDiva
ImageJ
GraphPad Prism
Quantity
[UNK] LT

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