PMID: 2506091Aug 1, 1989Paper

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in type 2 (non-insulin-dependent) diabetes mellitus

Diabetologia
L GroopJ Eriksson

Abstract

Which therapy should be used in Type 2 (non-insulin-dependent) diabetic patients with "secondary sulfonylurea failure", insulin or a combination of sulfonylurea and metformin? To address this question, we have compared the effect of 6 months of insulin therapy twice daily with that of a combination of glibenclamide and metformin in 24 Type 2 diabetic subjects, who no longer responded to treatment with sulfonylureas. Both treatments resulted in an equivalent 30% improvement in mean daily blood glucose (p less than 0.001), without significant effect on serum lipids. Insulin improved glycaemic control primarily by reducing basal hepatic glucose production (p less than 0.05), but had no significant effect on peripheral glucose metabolism. The combination of glibenclamide and metformin enhanced significantly total body glucose metabolism (p less than 0.05), predominantly by stimulating the non-oxidative pathway. Neither insulin nor the combination therapy altered B-cell response to a test meal. Insulin therapy resulted in a 6% increase in body weight, 63% of which was accounted for by increased fat mass. Although body weight was unchanged during sulfonylurea/metformin therapy, lean body mass and energy expenditure decreased signific...Continue Reading

Citations

Apr 1, 1994·Diabetes/metabolism Reviews·A E PontiroliG Pozza
Sep 1, 1995·Diabetes/metabolism Reviews·I W Campbell, H C Howlett
Nov 1, 1993·General Pharmacology·C J Bailey
Jul 1, 1997·Diabetes Research and Clinical Practice·F GregorioP Filipponi
Dec 1, 2001·Endocrinology and Metabolism Clinics of North America·S Mudaliar, S V Edelman
Nov 12, 1992·The New England Journal of Medicine·H Yki-JärvinenP Seppälä
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Mar 1, 1992·Journal of Internal Medicine·T SaneM R Taskinen
Oct 1, 1991·Australian and New Zealand Journal of Medicine·H D McIntyreD P Cameron
Oct 13, 2005·Diabetes, Obesity & Metabolism·Suzanne M Strowig, Philip Raskin
Mar 30, 2007·Diabetes, Obesity & Metabolism·A ErikssonF A Karlsson
Jun 26, 2007·Diabetes, Obesity & Metabolism·A ErikssonF A Karlsson
May 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·P K ChongC M Scrimgeour
Apr 4, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Adrian N C LauCatherine H Y Yu
Sep 1, 1996·Journal of Diabetes and Its Complications·N StucciF Tomasi
Jul 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·J WainsteinI Harman-Boehm
Oct 13, 2005·Diabetes, Obesity & Metabolism·Mark O Goodarzi, Michael Bryer-Ash
Mar 3, 2012·Diabetes Research and Clinical Practice·Emily G MoserSatish K Garg
Apr 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C A Mourão-JúniorS A Dib
Aug 28, 2007·Diabetes Research and Clinical Practice·Ohad CohenHilla Dekel
Jun 18, 2017·International Journal of Molecular Sciences·Daisuke SatoHiroshi Maegawa
Jan 30, 2004·Diabetes, Obesity & Metabolism·H de BoerL Verschoor
Jul 30, 2015·The Cochrane Database of Systematic Reviews·Bianca HemmingsenThomas P Almdal
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·J W Kolaczynski, J F Caro
Aug 24, 1999·Annals of Internal Medicine·R A DeFronzo
Oct 1, 2015·The Cochrane Database of Systematic Reviews·Antonio SaenzDavid Moher
Nov 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R J Mahler
Dec 1, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A SalléP Ritz

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