Different effects of metoclopramide and domperidone on arginine-vasopressin secretion in man

British Journal of Clinical Pharmacology
P ChioderaV Coiro

Abstract

This study was performed in order to investigate the dopaminergic mechanism involved in the control of arginine-vasopressin (AVP) secretion in normal men. Plasma AVP concentrations were measured before and after the administration of an i.v. bolus of 10 mg metoclopramide or domperidone to twelve healthy males. Metoclopramide, a cerebral and peripheral antagonist of dopaminergic receptors, significantly stimulated AVP secretion, whereas domperidone, a dopamine antagonist which does not cross the blood-brain barrier, was without effect. These data suggest that metoclopramide stimulates the release of AVP by blocking dopaminergic receptors in structures located inside the blood-brain barrier. Alternatively, it is possible that the stimulation of AVP release induced by metoclopramide does not occur through inhibition of dopamine receptors but rather through interaction with other neuroendocrine pathways.

References

Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M BaudryJ C Schwartz
Aug 1, 1976·Neuropharmacology·R Miller
Oct 1, 1983·Physiological Reviews·A H Sklar, R W Schrier
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Aug 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P ChioderaE Roti
Aug 1, 1984·Journal of Endocrinological Investigation·P ChioderaJ J Legros

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Citations

Aug 2, 1990·European Journal of Pharmacology·C Damase-MichelP Montastruc
Jul 27, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G E JacobsJ M A van Gerven

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