Different effects of novel stressors on sympathoadrenal system activation in rats exposed to long-term immobilization

Annals of the New York Academy of Sciences
Sladjana DronjakR Kvetnansky

Abstract

Activation of the sympathoadrenal system, evaluated by plasma levels of epinephrine (E) and norepinephrine (NE) after exposure of rats to various stressors, is well documented. However, response of rats exposed long-term to a homotypic stressor and then exposed once to a heterotypic novel stressor is poorly understood. In the present study, we examined changes in plasma levels of catecholamines (CA) and corticosterone (COR) of rats after a single (2-h) or long-term repeated immobilization (41 times, 2 h daily) and in rats adapted to long-term immobilization exposed once to the novel stress of cold exposure or insulin or 2-deoxy-D-glucose (2DG) administration. Long-term immobilization produced a significant elevation of basal plasma COR but not NE and E levels. Long-term immobilized rats exposed to insulin or 2DG showed significant elevation of plasma CA and COR levels in comparison to the administration to control rats. Exposure of long-term immobilized and control rats to cold stress increased plasma NE and COR, whereas plasma E was not significantly changed. The exposure of long-term immobilized rats to a further single immobilization (2 h) increased plasma CA levels, but, in naive control rats, the single immobilization prod...Continue Reading

References

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Citations

Dec 25, 2004·Obstetrical & Gynecological Survey·Sureshbabu N AhanyaMichael G Ross
Oct 16, 2007·Physiology & Behavior·Toshihiro Yoshihara, Yasutaka Yawaka
Mar 31, 2007·Journal of Neurochemistry·T C TaiDona L Wong
Jan 26, 2013·The Journal of Comparative Neurology·Lindsay M ParkerAnn K Goodchild
Jun 26, 2013·European Journal of Pharmacology·Anjana BaliAmteshwar Singh Jaggi
Jun 14, 2016·Stress : the International Journal on the Biology of Stress·Richard McCarty
Jun 18, 2016·Stress : the International Journal on the Biology of Stress·P VargovicR Kvetnansky
Oct 22, 2016·Psychoneuroendocrinology·Richard McCarty
Jun 6, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S Dronjak, L Gavrilovic
May 22, 2007·Stress : the International Journal on the Biology of Stress·Esther L Sabban, Lidia I Serova
May 22, 2007·Stress : the International Journal on the Biology of Stress·David S Goldstein, Irwin J Kopin
May 22, 2007·Stress : the International Journal on the Biology of Stress·D L Wong, A W Tank
Aug 7, 2009·Stress : the International Journal on the Biology of Stress·S HudecovaO Krizanova
May 16, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daisy L DaubertDeborah A Scheuer
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits

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