Different effects of physiologically and pharmacologically increased growth hormone levels on cholecalciferol metabolism at prepubertal age

The Journal of Steroid Biochemistry and Molecular Biology
M A Tryfonidou, H A Hazewinkel

Abstract

The aim of the study was to investigate the influence of physiologically and pharmacologically increased plasma growth hormone (GH) levels on cholecalciferol metabolism at prepubertal age. Three groups of dogs raised on the same diet were studied from weaning till 21 weeks of age, i.e., small breed dogs (n = 7, control group); large breed dogs with 15-fold greater growth rates compared to the control group (n = 8, LB-group); and small breed dogs treated with pharmacological doses of growth hormone (n = 6, GH-group; 0.5IU GH per kg body per day) from 12 to 21 weeks of age. Excess of GH had the expected anabolic effect on growth rate and phosphate sparing. Increased plasma GH levels in the LB- and GH-groups versus the control group were accompanied by (1) greater plasma insulin-like growth factor I (IGF-I) levels, (2) greater plasma 1,25-dihydroxycholecalciferol (1,25(OH)(2)D(3)) levels, and (3) lower plasma 24,25(OH)(2)D(3) levels. In the LB-group, excess of GH favored plasma 1,25(OH)(2)D(3) levels by decreasing the clearance of 1,25(OH)(2)D(3), whereas in the GH-group by increasing the production of 1,25(OH)(2)D(3). The lowered plasma 24,25(OH)(2)D(3) levels in the LB- and GH-groups were likely attributed to a competitive inhib...Continue Reading

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Nov 21, 2002·American Journal of Physiology. Endocrinology and Metabolism·M A TryfonidouH A W Hazewinkel

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Citations

Oct 29, 2011·Domestic Animal Endocrinology·R J CorbeeH A W Hazewinkel
Nov 7, 2006·The Veterinary Clinics of North America. Small Animal Practice·Susan D Lauten
Apr 26, 2006·Veterinary Surgery : VS·Andrea J Fascetti
Apr 14, 2015·Journal of Animal Physiology and Animal Nutrition·S KovácsA Liesegang
Jul 6, 2014·The Veterinary Journal·F FracassiM Caldin
Sep 23, 2010·American Journal of Physiology. Endocrinology and Metabolism·M A TryfonidouM Karperien

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