PMID: 9438798Jan 23, 1998Paper

Different effects of postnatal day 1 versus 7 192 immunoglobulin G-saporin lesions on learning, exploratory behaviors, and neurochemistry in juvenile rats

Behavioral Neuroscience
Laura RicceriJ Berger-Sweeney

Abstract

Passive avoidance learning and retention, as well as locomotor and exploratory behaviors, were assessed in rats after intraventricular 192 immunoglobulin G-saporin injections on either Postnatal Day 1 (PND1) or PND7. PND1-lesioned rats were not significantly impaired on acquisition or retention of passive avoidance. PND7-lesioned rats acquired the task slower than controls, but retention was not affected. PND7-lesioned rats were less exploratory than controls and showed reduced wall rearing. Histological analysis of PND1- and PND7-lesioned rats revealed no neuronal degeneration in hippocampus or cortex. There was a marked reduction of choline acetyltransferase (ChAT) activity in the hippocampus, cortex, and septum in the PND7-lesioned rats and a slight but significant ChAT depletion in the cortex of PND1-lesioned rats. These data suggest that the cholinergic system is critical for the learning of passive avoidance and exploratory behaviors in the developing rat.

Citations

May 21, 2005·Behavioural Brain Research·Maria Luisa ScattoniLaura Ricceri
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Christine F Hohmann
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Bruce A Pappas, Nicole Sherren
Dec 14, 2002·Brain Research. Developmental Brain Research·Diosely C SilveiraGregory L Holmes
Apr 21, 1999·Brain Research. Developmental Brain Research·N SherrenT Fortin
Jul 30, 2003·Genes, Brain, and Behavior·I Branchi, L Ricceri

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