PMID: 8953466Dec 1, 1996Paper

Different effects of somatostatin on in vitro growth hormone release in two porcine breeds with different growth rates

Journal of Neuroendocrinology
R TorronterasF Elsaesser

Abstract

A perifusion system of anterior pituitary (AP) tissue was used to investigate the temporal interaction of growth hormone-releasing factor (GRF) and somatostatin (SRIF) in the control of GH secretion in two pig breeds, Göttingen Miniature Pig (GMP), a small obese breed, and German Landrace (GLR), a conventional lean breed. AP tissue pieces derived from sexually mature ovariectomized animals were perifused (6 replicates per treatment) and fractions were collected at 10 min intervals. Basal GH release (ng.ml-1.mg-1 AP) in GLR was twice that of GMP (P < 0.001). Exposure to 10 min pulses of 1 nM GRF repeated 3 times at 2 h intervals resulted in rapid stimulatory GH responses (area under the curve) which became attenuated (P < 0.05) over time in GMP but not in GLR. Surprisingly, during and following the exposure of AP tissue from GMP to 10-, 20-, or 40-min pulses of 10 nM SRIF alone, GH release was markedly stimulated (P < 0.05), while AP tissue from GLR only showed a weak rebound GH release after SRIF pulses. With AP tissue from GLR low concentrations (0.1 nM SRIF) amplified GRF-induced GH release, whereas 1 nM or 10 nM SRIF inhibited GRF-induced GH release. However, concomitant exposure of AP tissue from GMP to 0.1, 1 or 10 nM SRIF...Continue Reading

References

Nov 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P M Dobado-BerriosF Gracia-Navarro
Oct 1, 1991·General and Comparative Endocrinology·F Gracia-NavarroR Torronteras
Apr 1, 1990·Domestic Animal Endocrinology·M L HeimanR D DiMarchi
Aug 1, 1985·General and Comparative Endocrinology·D A Porter, P Licht
Jul 22, 1982·Biochimica Et Biophysica Acta·P Lindström, J Sehlin

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