Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects

Transplantation
Inge H H T KleinGerry Ligtenberg

Abstract

The side effects of cyclosporine, nephrotoxicity and hypertension, contribute to long-term renal graft failure and cardiovascular morbidity in graft recipients. It is not clear whether tacrolimus is as nephrotoxic and hypertensive as cyclosporine. Data on this subject are not consistent because of differences in dosage and duration of treatment and the presence of comorbidity in the studied patients. A comparison of both drugs with respect to renal hemodynamics and blood pressure has not been performed yet in healthy subjects. We studied blood pressure, glomerular filtration rate, and effective renal plasma flow in eight healthy subjects at baseline and after 2 weeks administration of cyclosporine and tacrolimus, in randomized order. Trough levels of either drug were within the currently recommended therapeutical range of 100-200 ng/ml for cyclosporine and 5-15 ng/ml for tacrolimus. Tacrolimus did not influence renal hemodynamic parameters, in contrast to cyclosporine. During cyclosporine, glomerular filtration rate decreased from 98+/-9 ml/min/1.732 to 85+/-10 ml/min/1.732 (P<0.05), and ERPF decreased from 597+/-108 ml/min/1.732 to 438+/-84 ml/min/1.732 (P<0.01). Mean arterial blood pressure increased from 93+/-8 mmHg to 108+/...Continue Reading

References

Sep 13, 1990·The New England Journal of Medicine·U ScherrerR G Victor
Oct 27, 1994·The New England Journal of Medicine·UNKNOWN U.S. Multicenter FK506 Liver Study Group
May 1, 1995·Journal of the American Society of Nephrology : JASN·V J CanzanelloR A Krom
May 1, 1995·Kidney International·M J Bia
Dec 1, 1994·Mayo Clinic Proceedings·S C TextorR A Krom
Jan 1, 1996·Journal of the American Society of Nephrology : JASN·B L KasiskeJ Z Ma
Oct 1, 1996·Kidney International·W M BennettJ M Barry
Nov 1, 1996·American Journal of Hypertension·M SanderR G Victor
Mar 1, 1997·Journal of Hypertension·J M HansenS Strandgaard
Jul 3, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·V J CanzanelloR A Krom
Feb 4, 1999·Hypertension·Y TakedaH Mabuchi
Nov 27, 1999·Transplantation Proceedings·A D Mayer
Feb 9, 2000·JAMA : the Journal of the American Medical Association·K C MangeH I Feldman
Mar 4, 2000·The New England Journal of Medicine·S HariharanD Stablein
Mar 18, 2000·Kidney International·S T MorrisA G Jardine
Jul 26, 2000·Transplantation·J M Campistol, S H Sacks
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Gerry LigtenbergHein A Koomans
Sep 1, 1956·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HEYROVSKY

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Citations

Feb 16, 2005·Expert Opinion on Drug Safety·Ali J OlyaeiWilliam M Bennett
Jul 11, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Chi Yuen CheungChun Sang Li
Jun 26, 2010·Journal of Hypertension·Inge H H T KleinPeter J Blankestijn
Feb 5, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Karel KrejciJosef Zadrazil
Nov 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Paola FiorettoMichael Mauer
Jun 27, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paul D RobinsonHelen Spencer
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Richard N FormicaDavid Mulligan
Aug 2, 2016·World Journal of Hepatology·Luis Alberto Batista PeresRaphael Flavio Fachini Cipriani
Aug 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M Grinyó, J M Cruzado
Jun 18, 2004·Transplantation·M Roy First, William E Fitzsimmons
May 20, 2004·The British Journal of Dermatology·P-D GhislainJ-M Lachapelle
Aug 12, 2005·Journal of Hypertension·José M Morales, Beatriz Dominguez-Gil
Apr 11, 2008·Critical Care Medicine·Neesh Pannu, Mitra K Nadim
Feb 17, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maarten NaesensMinnie Sarwal
Aug 19, 2007·Plastic and Reconstructive Surgery·Dalibor VasilicE Steve Woodle
Nov 28, 2007·Journal of the American Society of Nephrology : JASN·Roy D Bloom, Peter P Reese
Mar 21, 2009·Transplantation·Susanne BeckebaumVito R Cicinnati
Mar 9, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio PonticelliGiorgio Graziani
Sep 7, 2016·Clinical Pulmonary Medicine·Leah J WittMary E Strek
Mar 31, 2019·Journal of Nephrology·Claudio Ponticelli, Richard J Glassock
Mar 24, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Josef ZadrazilPetr Bachleda
Oct 28, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Neill DuncanDavid Taube
Dec 8, 2004·Endocrine Reviews·Jennifer L Larsen
Apr 15, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Josef ZadrazilIvo Valkovsky
Mar 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernhard K KrämerUNKNOWN European Tacrolimus vs Cyclosporin Microemulsion Renal Transplantation Study Group
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D RushS Yilmaz
Jun 7, 2003·Transplantation·Sundaram Hariharan
Jun 18, 2004·Transplantation·Flavio Vincenti
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C A BögerB K Krämer
Aug 8, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Thorsten MarcardCornelia Blume
Jan 14, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Joanna Sańko-ResmerDouglas Thorburn
Aug 24, 2007·The New England Journal of Medicine·J Gary Abuelo
May 28, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathleen ClaesHenrik Ekberg
Aug 28, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Jeffrey S ZaltzmanDavid Z Cherney
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Jose María Morales, Beatriz Domínguez-Gil
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·Hanan H HagarMaha Arafa

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