Different epidermal growth factor receptor gene mutations in a patient with 2 synchronous lung cancers

Clinical Lung Cancer
Hirofumi NakanoShigeru Kohno

Abstract

Recently, the frequency of lung adenocarcinoma has been increasing among nonsmokers, though the etiology remains unclear. Mutations of the epidermal growth factor receptor (EGFR) gene are frequently detected in the lung adenocarcinomas seen in nonsmokers. Thus, EGFR mutations can be implicated in carcinogenesis of lung adenocarcinoma. Herein, we report a case of 2 synchronous lung adenocarcinomas composed of 2 distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary subtype of adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma. These findings suggest that specific mutations can occur randomly in the EGFR hot spot, and that these EGFR mutations can contribute to the distinct carcinogenic process of each adenocarcinoma.

References

Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shiu-Feng HuangShih-Feng Tsai
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tetsuya MitsudomiYasushi Yatabe
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshimi TakanoTomohide Tamura
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miguel TaronTeresa Moran
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daphne W BellDaniel A Haber

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Citations

Jan 29, 2010·Cancer Metastasis Reviews·Raj ChariWan L Lam
Sep 30, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jordan P ReynoldsJoseph C Cicenia
Sep 24, 2009·The American Journal of Surgical Pathology·Nicolas GirardWilliam D Travis
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Kentaro YoshimotoKanji Nagai

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