Different Erythrocyte MicroRNA Profiles in Low- and High-Altitude Individuals

Frontiers in Physiology
Liping SunDeqing Wang

Abstract

Background: The number of red blood cells (RBCs) increases significantly in response to high-altitude hypoxic environments, and the RBC microRNA (miRNA) expression pattern is similar to that in whole blood. Studies have shown that miRNA in plasma can act as a circulating hypoxia-associated marker, but the effect of a high-altitude hypoxic environment on RBC-derived miRNAs has not yet been reported. Methods: Blood samples were collected from 20 Han Chinese individuals residing at 500 m (Sichuan Han), 10 migrant Han Chinese citizens residing at 3,658 m (Tibet Han) and 12 native Tibetans, and RBC indices measurements and miRNA sequencing analyses were performed for the three sample groups. The levels of some markedly altered miRNAs at high altitude were subsequently measured from 5 randomly selected samples of each group by real-time PCR. Bioinformatic analyses was performed to determine the potential target genes of selected hypoxia-associated miRNAs. Results: Marked changes of several RBC indices were observed among the Tibet Han population, the Tibetan population and the Sichuan Han population. A total of 516 miRNAs derived from RBCs were initially identified by miRNA sequencing in the three sample groups. Compared with the Sic...Continue Reading

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Citations

Jun 9, 2020·Clinical and Translational Medicine·Kira GroenJeannette Lechner-Scott
Jun 26, 2020·Frontiers in Genetics·Liping SunDeqing Wang
May 20, 2020·The Journal of Experimental Biology·Hanane Hadj-Moussa, Kenneth B Storey
Dec 2, 2020·Database : the Journal of Biological Databases and Curation·Pankaj KhuranaBhuvnesh Kumar
Dec 17, 2020·American Journal of Hematology·Veronika MussackMichael W Pfaffl
Dec 31, 2020·International Journal of Molecular Sciences·Kiruphagaran ThangarajuPaul W Buehler
Nov 5, 2020·International Journal of Molecular Sciences·Deepika WattsBen Wielockx

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Datasets Mentioned

BETA
GSE117436

Methods Mentioned

BETA
PCR
FACS
Chip

Software Mentioned

TargetScan
Solexa
miRanda
miR
BLAST

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