PMID: 2499686Apr 1, 1989Paper

Different evolution rates within the lens-specific beta-crystallin gene family

Journal of Molecular Evolution
H J AartsJ G Schoenmakers

Abstract

We have determined the sequence of a rat beta A3/A1-crystallin complementary DNA (cDNA) clone and the (partial) sequence of the human beta B3-crystallin gene. Calculation of the ratio of silent to nonsynonymous substitution between orthologous beta A3/A1-, beta B3-, and other beta- and gamma-crystallin sequences revealed that the region encoding the two globular domains of the beta A3/A1-crystallin sequence is the best conserved during evolution, much better than the corresponding region of the beta B1-, beta B3-, or the gamma-crystallin sequences, and even better (at least in the rodent/frog comparison) than the well-conserved alpha A-crystallin sequence. Remarkably, the rate of change of the beta A3/A1-crystallin coding sequence does not differ in the rodent and primate lineages, in contrast with previous findings concerning the evolution rates of the alpha A- or gamma-crystallin sequences in these two lineages. Comparison of the regions that encode the four motifs of the beta-crystallin between orthologous mammalian sequences showed that the extent of nonsynonymous substitution in each of these four homologous motif regions is the same. However, when the orthologous beta-crystallin genes of more distantly related species (ma...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Aug 1, 1985·Molecular and Cellular Biology·M B SoaresA Efstratiadis
Apr 5, 1985·Journal of Molecular Biology·R J MoormannJ G Schoenmakers
Apr 1, 1987·Developmental Biology·R W van LeenJ G Schoenmakers
Jan 1, 1988·Annual Review of Biochemistry·G J Wistow, J Piatigorsky
Jan 1, 1987·Journal of Molecular Evolution·W H LiP M Sharp
Jan 1, 1988·Journal of Molecular Evolution·H J AartsJ G Schoenmakers
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J T den DunnenJ G Schoenmakers
May 5, 1986·Journal of Molecular Biology·J T den DunnenJ G Schoenmakers
Apr 19, 1985·Biochimica Et Biophysica Acta·J T den DunnenJ G Schoenmakers
Oct 1, 1985·Experimental Eye Research·H Bloemendal
Jan 1, 1985·Gene·J T den DunnenJ G Schoenmakers
Oct 10, 1981·Nucleic Acids Research·R J MoormannJ G Schoenmakers
Oct 15, 1983·Journal of Molecular Biology·G WistowT Blundell
Mar 15, 1984·European Journal of Biochemistry·G A BerbersG Braunitzer

❮ Previous
Next ❯

Citations

Feb 1, 1993·Protein Science : a Publication of the Protein Society·L R MiesbauerD L Smith
Nov 15, 1993·Gene·C Chambers, P Russell
Aug 11, 2004·Progress in Biophysics and Molecular Biology·Hans BloemendalAnnette Tardieu
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Priya R BanerjeeJayanti Pande
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W H LiY W Yang
Mar 25, 1990·Nucleic Acids Research
Aug 15, 2015·BioMed Research International·Tiancheng LiuYixue Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.