PMID: 9421366Jan 8, 1998Paper

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

International Journal of Cancer. Journal International Du Cancer
J BreivikG Gaudernack

Abstract

Mutations in the k-ras and TP53 genes, as well as microsatellite instability (MIN), are frequent genetic alterations in colorectal carcinomas and represent 3 different mechanisms in the carcinogenic process. Both the incidence of colorectal cancer and the frequency of genetic alterations in such tumours have been related to different clinico-pathological variables, including age and gender of the patient and location of the tumour. A number of studies have also reported associations between different types of genetic alterations. We therefore wanted to explore the relationship between these genetic and clinico-pathological variables using multivariate analysis on material from 282 colorectal carcinomas. Three logistic regression models were constructed: 1) the presence of K-ras mutations was dependent on MIN and age and gender of patient, with an especially low frequency among younger males and in tumours with MIN (overall p = 0.0003); 2) the presence of TP53 mutations was only dependent on tumour location, with a positive association to cancers occurring distally (p = 0.002); and 3) the presence of MIN was dependent on age, gender and K-ras and TP53 mutations, as well as on tumour location. MIN was most frequent among younger ...Continue Reading

References

Jul 2, 1992·Nature·D P Lane
Jun 1, 1991·Environmental Health Perspectives·G CapellaM Perucho
May 1, 1991·Diseases of the Colon and Rectum·H F VasenH T Lynch
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 1, 1988·Advances in Cancer Research·A G SchwartzL L Pashko
Jun 1, 1995·Current Opinion in Genetics & Development·R Fishel, R D Kolodner
Jul 19, 1995·Journal of the National Cancer Institute·J D Potter
Jul 23, 1994·Lancet·H S GohD R Smith
Feb 1, 1994·British Journal of Cancer·J BreivikG Gaudernack
Oct 28, 1993·Nature·S E Egan, R A Weinberg
Mar 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J J DeCosseW J Cennerazzo
Nov 1, 1995·Human Molecular Genetics·A L BørresenR D Kolodner
Apr 10, 1996·International Journal of Cancer. Journal International Du Cancer·M J BroedersD A Leon
May 1, 1996·Genes & Development·L J Ko, C Prives
Jul 1, 1996·British Journal of Cancer·S Norheim AndersenT O Rognum
Mar 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J ElnatanD R Smith
Feb 1, 1997·Molecular Medicine Today·R A Lothe
Feb 12, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·K V RolstonE B Rubenstein
Jul 16, 2004·Journal of Cellular Physiology·Manuela MigliavaccaAntonio Russo

❮ Previous
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Citations

May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A KonstantinopoulosA G Papavassiliou
Apr 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Tahereh MoradiStanley Lemeshow
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tuya PalThomas A Sellers
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jason A ZellHoda Anton-Culver
Aug 20, 2010·Cancer Prevention Research·Amy S OxentenkoPaul J Limburg
Oct 11, 2011·American Journal of Epidemiology·Laura A E HughesMatty P Weijenberg
Jan 10, 2012·Genetic Testing and Molecular Biomarkers·Esra TugEbru Kaplan Sahin
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Yong ZhangXiao-Feng Sun
Aug 10, 2012·American Journal of Public Health·Amanda I PhippsPolly A Newcomb
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Eva FernebroMef Nilbert
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T C Smyrk, H T Lynch
Jan 12, 2002·The American Journal of Pathology·Marius van RijnsoeverBarry Iacopetta
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul J LimburgDemetrius Albanes
May 7, 2014·BioMed Research International·Inés OmraneAmel Benammar-Elgaaied
Apr 28, 2005·International Journal of Cancer. Journal International Du Cancer·Hassan AshktorabFrancis M Giardiello
Nov 27, 2004·Journal of Surgical Oncology·Pascal GervazPhilippe Morel
Jun 11, 2005·Electrophoresis·David C HinselwoodPer O Ekstrøm
Nov 5, 2003·Journal of Surgical Oncology·Mark W A NorrieRobyn L Ward
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Anita KoushikDavid J Hunter
Feb 5, 2010·International Journal of Cancer. Journal International Du Cancer·Byonggu AnYoshitaka Sekido
Oct 31, 2009·Journal of Gastroenterology and Hepatology·Jenn Hian Koo, Rupert W L Leong
Dec 23, 2004·Seminars in Cancer Biology·Jarle Breivik
Mar 31, 2005·Cancer Letters·Elisenda VendrellMiguel A Peinado
Jul 1, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katsuhiko NoshoYasuhisa Shinomura
Jan 1, 2003·The Surgical Clinics of North America·Ernest T HawkJaye L Viner
Apr 6, 2001·The American Journal of Pathology·W S SamowitzM L Slattery

❮ Previous
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