Different Growth Patterns of Canine Prostatic Carcinoma Suggests Different Models of Tumor-Initiating Cells

Veterinary Pathology
S H AkterC Palmieri

Abstract

Controversies remain regarding the cell type from which human prostate cancer originates, and many attempts have been made to identify the cellular origin of canine prostate cancer but without definitive proof. This study aims to evaluate the expression of luminal (androgen receptor [AR], cytokeratin [CK]8/18) and basal (CK14, CK5) cell markers in different histologic subtypes of canine prostatic carcinoma (PC) and to suggest the most likely tumor-initiating cells. Normal prostates (n = 8) were characterized by AR+CK8/18+ luminal cells and few CK5+ basal cells, while CK14 was absent. Similar pattern was observed in all 35 prostates with benign prostatic hyperplasia, except few scattered CK14+ basal cells in 13 samples (37.14%). AR was localized in the nucleus of both normal and hyperplastic cells. In 34 samples of PC, the following growth patterns were identified: cribriform (44.12%), solid (32.35%), small acinar/ductal (20.59%), and micropapillary (2.94%). Most PCs expressed AR and CK8/18, while CK5 and CK14 expression was observed in 25% and 20% of cases, respectively. AR revealed a variable intracellular distribution, both nuclear and cytoplasmic. Solid PC was characterized by an undifferentiated or aberrant phenotype with a...Continue Reading

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Citations

Feb 21, 2016·Journal of Comparative Pathology·G HoodC Palmieri
May 29, 2016·Research in Veterinary Science·Luis Gabriel Rivera-CalderónRenée Laufer-Amorim
Jun 13, 2018·PloS One·Carlos Eduardo Fonseca-AlvesRenée Laufer-Amorim
Mar 31, 2019·International Journal of Molecular Sciences·Renée Laufer-AmorimSilvia Regina Rogatto
Jun 5, 2019·Journal of Comparative Pathology·S de BrotN P Mongan
May 1, 2021·Cancers·Giovana de Godoy FernandesCarlos Eduardo Fonseca-Alves

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