Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation
Scientific Reports
Sep 6, 2019
Dustin J E HuardRaquel L Lieberman
PMID: 31484937
Abstract
The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more
Mentioned in this Paper
RNA, Small Interfering
Neutrophil Migration, Function
Inhibitors
HSP90 Heat-Shock Proteins
Mass Spectrometry
HSP90B1
Protein Aggregation, Pathological
Amyloid
Amino-Terminal Amino Acid
Axial S
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Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation
Abstract
The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more
Mentioned in this Paper
RNA, Small Interfering
Neutrophil Migration, Function
Inhibitors
HSP90 Heat-Shock Proteins
Mass Spectrometry
HSP90B1
Protein Aggregation, Pathological
Amyloid
Amino-Terminal Amino Acid
Axial S
Related Papers
Paper Details
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