journal cover

Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

Scientific Reports

Sep 6, 2019

Dustin J E HuardRaquel L Lieberman

Abstract

The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more

Mentioned in this Paper

RNA, Small Interfering
Neutrophil Migration, Function
Inhibitors
HSP90 Heat-Shock Proteins
Mass Spectrometry
HSP90B1
Protein Aggregation, Pathological
Amyloid
Amino-Terminal Amino Acid
Axial S
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

Scientific Reports

Sep 6, 2019

Dustin J E HuardRaquel L Lieberman

PMID: 31484937

DOI: 10.1038/s41598-019-48751-8

Abstract

The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more

Mentioned in this Paper

RNA, Small Interfering
Neutrophil Migration, Function
Inhibitors
HSP90 Heat-Shock Proteins
Mass Spectrometry
HSP90B1
Protein Aggregation, Pathological
Amyloid
Amino-Terminal Amino Acid
Axial S

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/different-grp94-components-interact-transiently/31484937