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Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

Scientific Reports

Sep 4, 2019

Dustin J E HuardRaquel L. Lieberman

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Abstract

The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more

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Amyloid
Endoplasmic Reticulum
Glaucoma
Mass Spectrometry
Glucose-regulated protein GRP94
HSP90 Heat-Shock Proteins
Inhibitors
NUBP1 protein, human
Neutrophil Migration, Function
Glaucoma, Primary Open Angle
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Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

Scientific Reports

Sep 4, 2019

Dustin J E HuardRaquel L. Lieberman

PMID: 31484937

DOI: 10.1038/s41598-019-48751-8

Abstract

The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulat...read more

Mentioned in this Paper

Amyloid
Endoplasmic Reticulum
Glaucoma
Mass Spectrometry
Glucose-regulated protein GRP94

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