PMID: 9542901May 23, 1998Paper

Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels

Journal of Clinical Microbiology
M BeldJ Goudsmit

Abstract

Hepatitis C virus (HCV) infection often persists in association with chronic hepatitis. Different factors have been proposed to determine the clinical outcome of HCV infection. The aim of this study was to examine three different factors of HCV infection among injecting drug users. Nineteen untreated HCV seroconverters were tested longitudinally for the presence of HCV RNA by reverse transcriptase (RT) PCR, and results were quantified by the branched-DNA (bDNA) assay. HCV genotypes were determined with the first sample taken after HCV seroconversion. To assess the natural course of infection, serum alanine aminotransferase (ALT) levels were measured at three stages in every individual. The concordance between bDNA and RT-PCR was 98.9%. Three distinct patterns were found, according to the HCV RNA load after seroconversion during a mean follow-up period of 5 years (range, 1 to 8 years). HCV genotype 1a was predominant (52.6%). There was a significant increase in serum ALT levels (mean 55.5 U/liter) in the early phase of HCV infection, compared with basal serum ALT levels before HCV seroconversion and at the end of the follow-up period. Three distinct HCV RNA load profiles were found, without apparent relationship to genotype and ...Continue Reading

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Citations

Sep 1, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C MatheïF Buntinx
Feb 18, 2006·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Adel AlnaqySaid Al-Dhahry
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Jul 27, 2006·Digestive Diseases and Sciences·Haldun SelcukSedat Boyacioglu
Dec 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guang Y LiZhi Q Yao
Jul 30, 2003·The Medical Journal of Australia·Patrick G P CharlesM Lindsay Grayson
Sep 5, 2006·Virology Journal·Mostafa K El AwadyMahmoud M Bahgat

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