Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4

Molecular Neurobiology
Li Juan ZhengLong Jiang Zhang

Abstract

This study aims to explore the hippocampus-based functional connectivity patterns in young, healthy APP and/or presenilin-1/2 mutation carriers and APOE ε4 subjects. Seventy-eight healthy young adults (33 male, mean age 24.0 ± 2.2 years; 18 APP and/or presenilin1/2 mutation carriers [APP/presenilin-1/2 group], 30 APOE ε4 subjects [APOE ε4 group], and 30 subjects without the above-mentioned genes [control group]) underwent resting-state functional MR imaging and neuropsychological assessments. Bilateral hippocampus functional connectivity patterns were compared among three groups. The brain regions with statistical differences were then extracted, and correlation analyses were performed between Z values of the brain regions and neuropsychological results. Compared with control group, both APOE ε4 group and APP/presenilin-1/2 group showed increased functional connectivity in medial prefrontal cortex and precuneus for the seeds of bilateral hippocampi. The APOE ε4 group displayed increased functional connectivity from bilateral hippocampi to the left middle temporal gyrus compared with the control group. Moreover, compared with the APP/presenilin-1/2 group, the APOE ε4 group also had markedly increased functional connectivity in r...Continue Reading

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Citations

Mar 11, 2020·Frontiers in Aging Neuroscience·Marcelo FeboThomas C Foster
Nov 23, 2017·Frontiers in Molecular Neuroscience·Xin Y ZhangLong J Zhang
Feb 9, 2021·Frontiers in Aging Neuroscience·Joseph A McQuailThomas C Foster
Oct 17, 2021·The European Journal of Neuroscience·Gonzalo FornoMichael Hornberger

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Software Mentioned

DPABI
AlphaSim
SPSS
PickAtlas
Statistical Parametric Mapping SPM8
Pick Atlas Tool

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