Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Pediatric Rheumatology Online Journal
Marija JelusicSeza Özen

Abstract

Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognosis and treatment selection depends on the mode of interpretation of biopsy material, in this manuscript we have presented several issues related to the uneven application of different histological classifications in IgAV/Henoch-Schönlein purpura nephritis (HSPN). The nephritis of IgAV/IGAV/HSP will be abbreviated as HSPN for this paper. In clinical practice we use different histological classifications for HSPN. It is not known which of these classifications best correlates with severity of renal disease and renal outcome in IgAV/IGAV/HSP. One of the major problem with existing histological classifications is that there is no consensus on the implementation of biopsy in the treatment of HSPN. There is a histologic classification system conventionally used in HSPN, of the International Study of Kidney Disease in Children (ISKDC). On the other hand there is the new classification system suggested for IgA nephropathy, the Oxford classification. The latter has been validated only in IgA nephropathy. There are also two further ...Continue Reading

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Citations

Dec 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mikael KoskelaTimo Jahnukainen
Nov 22, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Licia Peruzzi, Rosanna Coppo
Feb 17, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marija Jelusic, Mario Sestan
Apr 28, 2021·International Urology and Nephrology·Xinyao LuoYahong Hu
Jul 2, 2021·Current Rheumatology Reports·Kinanah YaseenAlexandra Villa-Forte
Jul 31, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Mehtap Akbalik KaraAyşe Balat
Sep 10, 2021·BMC Pediatrics·Ling HouYue Du
Oct 9, 2021·Pediatric Rheumatology Online Journal·Małgorzata Mizerska-WasiakMałgorzata Pańczyk-Tomaszewska

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Methods Mentioned

BETA
biopsy
biopsies

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