Apr 24, 2020

Different immunomodulatory role of Ly6Ghi and Ly6Gint neutrophils during antiviral antibody therapy

BioRxiv : the Preprint Server for Biology
J. LambourMireia Pelegrin

Abstract

Antiviral monoclonal antibodies (mAbs) can generate protective immunity through immune complexes (IC)-Fc{gamma}Rs interactions. We have shown the essential role of neutrophils in mAb-induced immunity of retrovirus-infected mice. Using this model, here we addressed how viral infection, with or without mAb therapy, affects the functional activation of neutrophils. We found that neutrophils activated by viral ICs secreted high levels of chemokines able to recruit monocytes and neutrophils themselves. Moreover, inflammatory cytokines potentiated chemokines and cytokines release by IC-activated cells and induced Fc{gamma}Rs upregulation. Similarly, infection and mAb-treatment upregulated Fc{gamma}Rs expression on neutrophils and enhanced their cytokines and chemokines secretion. Fc{gamma}Rs upregulation allowed to identify in vivo two splenic neutrophils subpopulations with distinct phenotypic and functional properties that differentially and sequentially collaborate with inflammatory monocytes to induce Th1-type responses in mAb-treated mice. Our work provides novel findings on the heterogeneity and the immunomodulatory role of neutrophils in the enhancement of immune responses upon antiviral mAb therapy.

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Mentioned in this Paper

Nasopharyngeal Carcinoma
Biological Neural Networks
Pluripotent Stem Cells
Spatial Distribution
Brain
Neurodevelopmental Disorders
Electrical Activity of Brain
Neuroepithelium
Neural Stem Cells
Cell Differentiation Process

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