Different impacts of C-reactive protein and lipid profile on coronary lesions following a percutaneous coronary intervention

Coronary Artery Disease
Hai-yan XuJian-jun Li

Abstract

In-stent restenosis (ISR) and lesion progression are major obstacles for a percutaneous coronary intervention (PCI). Although previous studies have suggested that inflammation and lipid profile may be involved in those pathophysiological events, it remains controversial to date. The aim of the present study was to investigate the impacts of inflammation and lipid profile on both ISR and lesion progression in patients receiving PCI and scheduled follow-up. A retrospective analysis of 513 patients was performed in patients who underwent PCI and received coronary angiography again at an average of 7 months. The data of lipid profile and C-reactive protein (CRP) at both pre-PCI and follow-up were analyzed in patients with 94 ISR group and 65 lesion progression (progression group) alone, which was compared with 307 patients with neither ISR nor lesion progression (control group). CRP levels at pre-PCI in the ISR group were higher than those in the control group (P<0.05). The multivariate analysis indicated that the CRP levels at both pre-PCI and follow-up were significantly correlated with ISR [odds ratio (OR)=1.095, 95% confidence interval (CI) 1.005-1.194 for pre-PCI, OR=1.156, 95% CI 1.054-1.267 for follow-up, P<0.05, respectivel...Continue Reading

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Jan 17, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Abdulkadir YildizMehmet Siddik Ulgen

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