Abstract
To investigate the protein expression of vascular endothelial growth factor (VEGF) isoforms in relation to the clinical course in patients with different renal cell carcinoma (RCC) types, as angiogenesis is essential for tumour growth and metastasis. Western blots were assayed of protein extracts from tumour and concomitant kidney cortex samples from 96 patients. The levels of VEGF189, VEGF165, and VEGF121 isoforms were correlated with clinicopathological characteristics and survival. VEGF189 levels were significantly higher in kidney cortex and chromophobe RCC than in papillary and conventional RCC. In papillary RCCs, VEGF189 levels correlated inversely with tumour stage and tumour size. VEGF165 levels were higher in kidney cortex than in RCC, but there was no difference among the RCC types. VEGF121 expression was associated with less advanced tumour stage in conventional RCC. Using multivariate analysis, VEGF189 remained as an independent prognostic factor for patients with papillary RCC. VEGF189 was associated with tumour progression; in papillary RCC, VEGF189 was a significant independent prognostic factor. VEGF protein isoform patterns differed among the specific RCC types. Additional knowledge is essential to design new a...Continue Reading
References
May 1, 1976·The Journal of Urology·R A BlathR J Stanley
Nov 1, 1971·Cancer·D G SkinnerW F Leadbetter
Dec 1, 1993·Molecular Biology of the Cell·J E ParkN Ferrara
Mar 29, 1996·The Journal of Biological Chemistry·B A KeytN Ferrara
Jun 1, 1997·The Journal of Urology·M W JacksonW D Tilley
May 16, 1997·The Journal of Biological Chemistry·J PlouëtF Bayard
May 1, 1997·British Journal of Urology·M NakagawaY Nomura
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Y ChengW K Cavenee
Apr 7, 1999·American Journal of Clinical Pathology·A A Renshaw, J P Richie
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M TomisawaM Nakamura
Sep 4, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J BriegerH J Decker
Jun 2, 2000·Virchows Archiv : an International Journal of Pathology·V ParadisP Bedossa
Jun 9, 2000·Kidney International·J KanellisD A Power
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Sep 6, 2001·Oncogene·X MaK Hemminki
Oct 25, 2001·Yonsei Medical Journal·K H SongJ Song
Nov 10, 2001·Pathology, Research and Practice·K T MaiJ Collins
Apr 20, 2002·European Journal of Clinical Nutrition·J A BarnardL H Storlien
Jul 13, 2002·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Jul 20, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J JacobsenB Ljungberg
Apr 16, 2003·Journal of Clinical Laboratory Analysis·Ching-Chiang YangWen-Meng Yeh
Oct 24, 2003·Urological Research·Börje LjungbergKjell Grankvist
Feb 7, 2004·BJU International·J JacobsenB Ljungberg
May 15, 2004·BJU International·E YildizE Y Gultekin
Citations
May 17, 2011·Investigational New Drugs·Sylvie Négrier, Eric Raymond
Jan 24, 2007·Current Urology Reports·Peggy Soung SullivanRichard J Cote
Jan 24, 2007·Current Urology Reports·Matthew K TollefsonBradley C Leibovich
Nov 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Begoña Mellado, Pere Gascón
Feb 2, 2011·PloS One·Ang YuanChen Chang
Mar 17, 2009·Future Oncology·S Elena GimenezJay D Raman
Jun 22, 2012·Expert Opinion on Drug Discovery·Jessie M Wu, Carolyn A Staton
Jul 19, 2011·Hematology/oncology Clinics of North America·Simon ChowdhuryNizar M Tannir
Jun 29, 2007·Human Pathology·Nathalie Rioux-LeclercqJean-Jacques Patard
Aug 24, 2006·BJU International·Börje J LjungbergTorgny Rasmuson
Jul 4, 2006·European Urology·Anders LidgrenBörje Ljungberg
Jul 22, 2015·British Journal of Cancer·Melanie Di BenedettoMartine Perrot-Applanat
Aug 31, 2018·The British Journal of Radiology·Chryso Kanthou, Gillian Tozer
Sep 1, 2007·Current Opinion in Urology·Börje Ljungberg
Sep 4, 2007·International Journal of Cancer. Journal International Du Cancer·Seung-Hyun OhHo-Young Lee
May 15, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong HuangJean-Pierre Lavoie
Mar 12, 2009·Expert Review of Anticancer Therapy·Simon Chowdhury, Toni K Choueiri
Jun 18, 2010·Expert Review of Anticancer Therapy·Jay B Shah, Vitaly Margulis
Jul 6, 2020·BMC Cancer·Marcela GarcíaDiana Tronik-Le Roux
Dec 18, 2018·Frontiers in Oncology·Christina WohlrabGabi U Dachs
Nov 17, 2007·Cancer Research·Masaki KunizakiYoichi Furukawa
Apr 3, 2008·Cancer Research·Gillian M TozerChryso Kanthou
Oct 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ingrid M E DesarWim J G Oyen
Dec 5, 2006·Current Opinion in Nephrology and Hypertension