PMID: 6163230Jan 1, 1980Paper

Different levels of changes induced by the insecticide lindane in cultured C-6 glioma cells

Toxicology
F RouxE Fournier

Abstract

The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-aminoisobutyric acid and uridine uptake was rapid and immediately reversible. The other study, carried out after several hours of treatment followed by a 15-min triple washing, has allowed to attribute the non-reversible decrease in uridine uptake induced by a 20-h treatment to an inhibition of protein synthesis, and the increase in alpha-aminoisobutyric acid uptake to the derepression of synthesis of transport proteins.

Citations

Nov 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V HernoF Erb
May 1, 1990·Neurotoxicology and Teratology·J M DavisL D Grant

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