Different mechanisms of L-arginine induced dilation of brain arterioles in normotensive and hypertensive rats

Brain Research
M W RiedelR L Haberl

Abstract

We evaluated the response of pial arterioles to L-arginine in anesthetized normotensive rats and spontaneously hypertensive rats equipped with a closed cranial window. Topical application of 10(-6)-10(-4) mol/l L-arginine, which is known to be the endogenous substrate for the synthesis of nitric oxide, induced dose-dependent arteriolar vasodilation. The response was more pronounced in hypertensive than in normotensive rats (at the concentration of 10(-4) mol/l L-arginine: 18.3 +/- 3.3% vs. 6.7 +/- 1.7%, respectively, means +/- S.E.). The stereoisomer D-arginine had no effect in hypertensive rats. Topical application of the nitric oxide synthase inhibitor N-nitro-L-arginine converted L-arginine-induced dilation to constriction in normotensive and hypertensive rats. The cyclooxygenase inhibitor indomethacin (5 micrograms/ml cerebrospinal fluid) also blocked the dilation in both strains. Photochemical endothelial injury blocked L-arginine-induced dilation in normotensive rats, but only partly antagonized the response in hypertensive animals. Intravenous or topical pretreatment with the free radical scavenger superoxide dismutase significantly reduced the dilating response to 10(-4) mol/l L-arginine in hypertensive rats. Superoxide...Continue Reading

References

Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·R SchleifferA Gairard
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Oct 1, 1990·Hypertension·J J Marshall, H A Kontos
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H W PfisterK M Einhäupl
Aug 1, 1988·Hypertension·G L Baumbach, D D Heistad
May 1, 1986·Stroke; a Journal of Cerebral Circulation·W I Rosenblum

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Citations

Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R PradoM D Ginsberg
Nov 17, 1998·Journal of Neurosurgery·K WadaW D Dietrich
Sep 11, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marilyn J CipollaSiu-Lung Chan
Apr 25, 2000·Journal of Cardiovascular Pharmacology·J WidderL Schilling
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad

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