Different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours

Nuclear Medicine Communications
Hans JacobssonStig A Larsson

Abstract

This study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patient cohort from a previous study assessing the response to neoadjuvant chemotherapy for breast cancer using Tc-hexakis-2-methoxyisobutylisonitrile (Tc-sestamibi). The tumour uptake in 29 women with locally advanced breast cancer was examined using Tc-sestamibi and SPECT before neoadjuvant chemotherapy and, on average, 19 days after one chemotherapy cycle. The histology of the finally resected tumour confirmed a therapeutic response. Different assessments of the uptake, various levels of background activity subtraction and different reference tissues for relative activity calculations were used. The tumour uptake and activity of the reference tissues were also related to the administered activity. Different definitions of tumour activity had little influence. Relating the tumour uptake to a large portion of the abdomen, as well as visual evaluation, showed a therapeutic response. Comparison with the administered activity...Continue Reading

References

Jan 1, 1984·Breast Cancer Research and Treatment·G CocconiG Peracchia
Jul 1, 1995·CA: a Cancer Journal for Clinicians·G BonadonnaB Salvadori
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Dec 24, 1997·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·W T YangC Metreweli
Jun 30, 2001·Seminars in Nuclear Medicine·G J Cook, I Fogelman

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Citations

Sep 1, 2004·Radiologic Clinics of North America·David M Schuster, Raghuveer K Halkar

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