Aug 1, 2009

Different molecular patterns in glioblastoma multiforme subtypes upon recurrence

Journal of Neuro-oncology
Ramon MartinezGabriele Schackert

Abstract

One of the hallmarks of glioblastoma is its inherent tendency to recur. At this point patients with relapsed GBM show a survival time of only few months. The molecular basis of the recurrence process in GBM is still poorly understood. The aim of the present study was to investigate the genetic profile of relapsed GBM compared to their respective primary tumors. We have included 20 paired GBMs. In all tumor samples, we have analyzed p53 and PTEN status by sequencing analysis, EGFR amplification by semiquantitative PCR and a wide-genome fingerprinting was performed by microsatellite analysis. Among primary GBM, we observed twelve type 2 GBM, four type 1 GBM and four further GBM showing neither p53 mutations nor EGFR amplification (non-type 1-non-type 2 GBM). Upon recurrence, we have detected two molecular patterns of tumor progression: GBM initially showing either type 1 or type 2 profiles conserved them at the time of relapse. In contrast, non-type 1-non-type 2 GBM acquired the typical pattern of type 2 GBM and harbor EGFR amplification without p53 mutation. New PTEN mutations upon relapse were only detected in type 2 GBM. Additional LOH were more frequently identified in relapses of type 2 GBM than in those showing the type 1 s...Continue Reading

Mentioned in this Paper

Glioblastoma Multiforme
Short Tandem Repeat
Genomic Profile
Primary Neoplasm
Epidermal Growth Factor Receptor Activity
Recurrent Malignant Neoplasm
Gene Amplification Technique
Soluble ErbB-1
EGFR protein, human
Sequencing

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