Different mutations in SARS-CoV-2 associate with severe and mild outcome.

International Journal of Antimicrobial Agents
Ádám NagyBalázs Győrffy


Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome. Mutations in viral sequences from the GISAID virus repository were evaluated by using "hCoV-19/Wuhan/WIV04/2019" as the reference. Patient outcomes were classified as mild disease, hospitalization and severe disease (death or documented treatment in an intensive-care unit). Chi-square test was applied to examine the association between each mutation and patient outcome. False discovery rate was computed to correct for multiple hypothesis testing and results passing FDR cutoff of 5% were accepted as significant. Mutations were mapped to amino acid changes for 3,733 non-silent mutations. Mutations correlated to mild outcome were located in the ORF8, NSP6, ORF3a, NSP4, and in the nucleocapsid phosphoprotein N. Mutations associated with inferior outcome were located in the surface (S) glycoprotein, in the RNA dependent RNA polymerase, in ORF3a, NSP3, ORF6 and N. Mutations leading to severe outcome with low prevalence were found in the ORF3A and in NSP7 proteins. Four out of 22 of the most significant mutation...Continue Reading


Feb 15, 2005·Journal of Virology·Leen VijgenMarc Van Ranst
Feb 23, 2020·Journal of Medical Virology·Silvia AngelettiMassimo Ciccozzi
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Peter ForsterMichael Forster
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 24, 2020·Journal of Translational Medicine·Maria PachettiRudy Ippodrino
May 11, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lucy van DorpFrançois Balloux
May 12, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Audrey Giraud-GatineauDidier Raoult
Jul 9, 2020·BioRxiv : the Preprint Server for Biology·Leonid YurkovetskiyJeremy Luban
Oct 1, 2020·MedRxiv : the Preprint Server for Health Sciences·Kenji NakamichiRussell N Van Gelder
Oct 8, 2020·MedRxiv : the Preprint Server for Health Sciences·Scott Wesley LongJames Musser

❮ Previous
Next ❯


Feb 13, 2021·Pathogens·Alejandro Flores-AlanisRosario Morales-Espinosa
Apr 3, 2021·Journal of Biomolecular Structure & Dynamics·Neha PeriwalVikas Sood
Mar 27, 2021·Environmental Microbiology·Ruibang LuoAntoine Danchin
May 1, 2021·Epidemiology and Infection·Parinita Majumdar, Sougata Niyogi
Jul 3, 2021·Journal of Clinical Medicine·Thi Loi DaoPhilippe Gautret
Aug 18, 2021·Briefings in Functional Genomics·Ranjeet MauryaRajesh Pandey
Aug 26, 2021·Communications Biology·Florian A JochheimPatrick Cramer
Oct 12, 2021·International Journal of Immunopathology and Pharmacology·Gabriela Athziri Sánchez-ZunoJosé Francisco Muñoz-Valle

❮ Previous
Next ❯

Datasets Mentioned


Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved