PMID: 8614252Mar 10, 1995Paper

Different neurotransmitter systems are involved in the development of esophageal achalasia

Life Sciences
S SigalaP Spano

Abstract

Clinical and pharmacological evidence suggests that several neurotransmitters are involved in the control of the esophageal motility; in fact, besides the well known cholinergic and sympathetic innervation, Vasoactive Intestinal Polypeptide (VIP)-containing fibers as well as dopamine (DA)-containing nerve endings have been identified within the esophageal wall. Lower Esophageal Sphincter (LES) achalasia is a neuromuscular disorder characterized by the absence of peristalsis in the body of the esophagus and by the failure of the LES to relax in response to swallowing. Stimulation of both VIP receptors and D-2 DA receptors induce a decrease in LES pressure, while D-1 receptors mediates LES contractions. In the present study we show that both VIP and DA system is disregulated in LES achalasia. In particular, this disease is associated not only with the lack of VIP nerves in the LES, but also with a failure in the responsiveness of postsynaptic receptors to VIP stimulation. Furthermore, we demonstrate a selective functional loss of the D-2 DA receptor component, without changes in the D-1 DA receptor mediated responses.

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Citations

Mar 12, 2004·Journal of Gastroenterology and Hepatology·Zi-Qiang TianYue-Feng Zhang
May 1, 2008·Journal of Gastroenterology and Hepatology·Jun-Feng LiuQi-Zhang Wang
Mar 1, 2012·Journal of Gastroenterology and Hepatology·Xin-Bo Liu, Jun-Feng Liu
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A VerhagenA J Smout
Dec 14, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kohsuke Uchida, Yuichiro Kamikawa
Nov 1, 2011·Digestive Diseases and Sciences·Ashish NimgaonkarGeorge Triadafilopoulos
Oct 22, 2008·Progress in Neurobiology·Andrew HubballCharles H Knowles
Jun 20, 2015·Gut and Liver·Fehmi Ates, Michael F Vaezi
Oct 28, 2016·Annals of the New York Academy of Sciences·Michael F VaeziErwin Rieder
Jun 3, 2005·The American Journal of Gastroenterology·Woosuk Park, Michael F Vaezi
Oct 17, 2009·Journal of Clinical Gastroenterology·Vincenzo VillanacciGabrio Bassotti
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J VaughanD P O'Connell
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Louiza Belkacemi, Nissar A Darmani

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