PMID: 11920640Mar 29, 2002Paper

Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix

International Journal of Cancer. Journal International Du Cancer
H TsudaSetsuo Hirohashi

Abstract

It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases of endocervical type, 12 cases of endometrioid type and 7 cases of adenoma malignum without the component of conventional endocervical-type adenocarcinoma (designated as "pure" form). In adenocarcinomas of endocervical type and endometrioid type, LOH was commonly detected on chromosome arms 17p (62% and 50%, respectively), 1p (33% and 67%) and 22q (40% and 33%). In addition, endocervical-type adenocarcinoma frequently (> or = 30%) showed LOH on 18p (71%), 19q (50%), 19p (38%) and 16q (38%), whereas endometrioid-type adenocarcinoma frequently showed LOH on 10q (43%) and 5q (40%). LOH was only sporadically detected on 9q, 18q, or 21q in 3 of 7 cases of "pure" adenoma malignum. In a case of coexistence of "pure" adenoma malignum and adenocarcinoma in situ (AIS), LOH on 1q, 5p, 11p, 17p, 18p and 18q was detected only in AIS. LOH was accumulated on a number of chromosome arms in the adenocarcinoma at the early developmen...Continue Reading

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Citations

Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michael Wells, Laurence J R Brown
Jan 27, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M YasudaT Shinozuka
Jan 12, 2005·Cancer Genetics and Cytogenetics·Carola NordlanderKarin Klinga Levan
Jul 21, 2004·Gynecologic Oncology·Kentaro MiyaiHiroaki Fujii
Jun 3, 2004·Cancer Letters·Takeo MinaguchiYuji Taketani
Aug 27, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Paul L SeversonBernard W Futscher
Apr 15, 2004·British Journal of Cancer·M M SasiadekN Blin
Mar 26, 2013·International Journal of Molecular Medicine·Junjie QuXiaoping Wan

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